ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2016.12.044
Abstract: Human apolipoprotein E (ApoE) apolipoprotein is primarily expressed in three isoforms (ApoE2, ApoE3, and ApoE4) that differ only by two residues. ApoE4 constitutes the most important genetic risk factor for Alzheimer's disease (AD), ApoE3 is… read more here.
Keywords: transcription; app transcription; kinase; apoe3 apoe4 ... See more keywords
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-022-00516-0
Abstract: Background One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E ( APOE ) gene is the strongest genetic risk factor… read more here.
Keywords: accumulation; apoe3 apoe4; apoe; pathology ... See more keywords