ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.09.029
Abstract: Though apolipoprotein E ε4 (APOE ε4) is a major genetic risk factor for late-onset Alzheimer's disease, its association with depression remains controversial. In present study, 3-month-old and 8-month-old apoE-targeted replacement (TR) mice were both subjected… read more here.
Keywords: depression; month old; stress; apoe4 ... See more keywords
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function
Sign Up to like & getrecommendations! Published in 2021 at "Neuron"
DOI: 10.1016/j.neuron.2020.11.019
Abstract: The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's disease (AD) and multiple vascular conditions. ApoE is abundantly expressed in multiple brain cell types, including astrocytes, microglia,… read more here.
Keywords: behavior modulating; vascular apoe4; impairs behavior; apoe4 ... See more keywords
Nutritional Ketosis and photobiomodulation remediate mitochondria warding off Alzheimer's disease in a diabetic, ApoE4+ patient with mild cognitive impairment: A case report.
Sign Up to like & getrecommendations! Published in 2020 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2020.101777
Abstract: Alzheimer's Disease (AD) is a neurodegenerative progressive disorder for which there is currently no cure. Recently, there has been a robust correlation between type-2 diabetes mellitus (T2DM) and the development of MCI and AD, which… read more here.
Keywords: alzheimer disease; disease; photobiomodulation; case ... See more keywords
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2021.102032
Abstract: ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription… read more here.
Keywords: alzheimer disease; pathogenesis; apoe4; ebp secretase ... See more keywords
Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40668
Abstract: Alzheimer’s disease affects tens of millions of people worldwide and its prevalence continues to rise. It is caused by a combination of a subject’s heredity, environment, lifestyle, and medical condition. The most significant genetic risk… read more here.
Keywords: alzheimer disease; disease; apoe4; nuclear respiratory ... See more keywords
Apolipoprotein E4 inhibits γ‐secretase activity via binding to the γ‐secretase complex
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15750
Abstract: The mechanisms of amyloid accumulation in familial Alzheimer's disease (FAD) and sporadic AD (SAD) are controversial. In FAD, mutations in presenilin (PSEN) impair γ‐secretase activity and lead to abnormal amyloid β–protein (Aβ) production, thereby increasing… read more here.
Keywords: apoe4; secretase complex; production; activity ... See more keywords
Interaction between arteriosclerosis and the APOE4 gene in cognitive decline in older adults: a cross‐sectional study in rural minority areas in western China
Sign Up to like & getrecommendations! Published in 2022 at "Psychogeriatrics"
DOI: 10.1111/psyg.12808
Abstract: Numerous studies have confirmed that the apolipoprotein E4 allele (APOE4) gene and arteriosclerosis (AS) have a combined effect on the occurrence of cognitive function impairment, and dyslipidaemia levels are significantly correlated with APOE4 levels and… read more here.
Keywords: arteriosclerosis; apoe4; apoe4 gene; study ... See more keywords
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaz4564
Abstract: APOE4-disrupted intracellular lipid homeostasis in human and yeast cells was reversed by promoting phospholipid synthesis through choline supplementation. APOE4 disrupts lipid homeostasis in glia APOE4 is a strong genetic risk factor for many diseases, most… read more here.
Keywords: intracellular lipid; ipsc derived; apoe4; lipid homeostasis ... See more keywords