In Thai Nationals, the ApoE4 Allele Affects Multiple Domains of Neuropsychological, Biobehavioral, and Social Functioning Thereby Contributing to Alzheimer’s Disorder, while the ApoE3 Allele Protects Against Neuropsychiatric Symptoms and Psychosocial Deficits
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0848-0
Abstract: The apolipoprotein E epsilon 4 (ApoE4) allele is the strongest genetic risk factor for Alzheimer’s disorder (AD) and is associated with semantic and episodic memory deficits. The aim of this study was to examine the… read more here.
Keywords: disorder; neuropsychiatric symptoms; apoe4 carriers; alzheimer disorder ... See more keywords
Relationship of Muscle Apolipoprotein E Expression with Markers of Cellular Stress, Metabolism, and Blood Biomarkers in Cognitively Healthy and Impaired Older Adults
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DOI: 10.3233/jad-221192
Abstract: Background: Individuals with mild cognitive impairment (MCI) have reduced lipid-stimulated mitochondrial respiration in skeletal muscle. A major risk factor for Alzheimer’s disease (AD), the apolipoprotein E4 (APOE4) allele, is implicated in lipid metabolism and is… read more here.
Keywords: stress; relationship; apoe4 carriers; muscle ... See more keywords
APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM2.5 Polluted Cities
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DOI: 10.3390/biom13060927
Abstract: This Review emphasizes the impact of APOE4—the most significant genetic risk factor for Alzheimer’s disease (AD)—on peripheral and neural effects starting in childhood. We discuss major mechanistic players associated with the APOE alleles’ effects in… read more here.
Keywords: impact apoe4; disease; apoe4 carriers; risk ... See more keywords
Vascular Dysfunction Is Central to Alzheimer’s Disease Pathogenesis in APOE e4 Carriers
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DOI: 10.3390/ijms23137106
Abstract: Alzheimer’s disease (AD) is the most common form of dementia and the leading risk factor, after age, is possession of the apolipoprotein E epsilon 4 allele (APOE4). Approximately 50% of AD patients carry one or… read more here.
Keywords: pathology; apoe4 carriers; vascular dysfunction; brain ... See more keywords
APOE Genotypes Modulate Inflammation Independently of Their Effect on Lipid Metabolism
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DOI: 10.3390/ijms232112947
Abstract: The association between APOE genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS)… read more here.
Keywords: apoe genotypes; apoe4 carriers; ldl particles; crp levels ... See more keywords
Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers
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DOI: 10.3390/nu13041362
Abstract: The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. Precision nutrition targeting metabolic pathways altered by ApoE4 provides a… read more here.
Keywords: precision nutrition; risk; apoe4 carriers; nutrition ... See more keywords