SNPs at 3′UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studies
Sign Up to like & getrecommendations! Published in 2021 at "Mammalian Genome"
DOI: 10.1007/s00335-021-09880-6
Abstract: Acute Kidney Injury (AKI) is a common manifestation of COVID-19 and several cases have been reported in the setting of the high-risk APOL1 genotype (common genetic variants). This increases the likelihood that African American people… read more here.
Keywords: sars cov; apol1; cov infection; mir 6741 ... See more keywords
APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.10.004
Abstract: The incidence and severity of sepsis is higher among individuals of African versus European ancestry. We found that genetic risk variants (RVs) in the trypanolytic factor apolipoprotein L1 (APOL1), present only in individuals of African… read more here.
Keywords: sepsis; individuals african; ancestry; apol1 ... See more keywords
Effect of APOL1 disease risk variants on APOL1 gene product
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DOI: 10.1042/bsr20160531
Abstract: Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution… read more here.
Keywords: risk; disease; apol1 variants; apol1 ... See more keywords
APOL1 Risk Variants Affect Podocyte Lipid Homeostasis and Energy Production in Focal Segmental Glomerulosclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Human molecular genetics"
DOI: 10.1093/hmg/ddab022
Abstract: Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is associated with the presence of genetic variants of the Apolipoprotein L1 gene (APOL1)… read more here.
Keywords: focal segmental; apol1 risk; segmental glomerulosclerosis; expression ... See more keywords
Obesity-related glomerulopathy in the presence of APOL1 risk alleles
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-249624
Abstract: Nephropathic apolipoprotein L1 (APOL1) risk alleles (G1/G2) have been associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, Systemic lupus erythematosus (SLE)-associated collapsing glomerulopathy and other glomerulonephritides. These alleles confer protection from Trypanosoma brucei infections which are… read more here.
Keywords: apol1; related glomerulopathy; obesity related; risk ... See more keywords
Early recurrence of focal segmental glomerulosclerosis in a kidney transplant recipient with APOL1 one risk variant
Sign Up to like & getrecommendations! Published in 2023 at "BMJ Case Reports"
DOI: 10.1136/bcr-2023-254593
Abstract: Apolipoprotein 1 (APOL1) risk variants (G1 and G2) are associated with focal segmental glomerulosclerosis (FSGS) in patients of African ancestry. The prevalence of APOL1 two risk variants is lower in Hispanics and very rare in… read more here.
Keywords: recipient; focal segmental; risk variant; kidney ... See more keywords
APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92581
Abstract: APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses or… read more here.
Keywords: protein; protein vamp8; apol1 variants; apol1 ... See more keywords
APOL1 and the risk of adverse renal outcomes in patients of African ancestry with systemic lupus erythematosus
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DOI: 10.1177/09612033231172660
Abstract: Background Systemic lupus erythematosus (SLE) disproportionately affects individuals of African ancestry (AA) compared to European ancestry (EA). In the general population, high risk (HR) variants in the apolipoprotein L1 (APOL1) gene increase the risk of… read more here.
Keywords: renal hypertensive; ancestry; systemic lupus; risk ... See more keywords
APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death.
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DOI: 10.1681/asn.2016050550
Abstract: People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of developing renal diseases. However, the mechanisms underlying APOL1-associated renal diseases are unknown. Because the APOL1 gene is unique to humans and… read more here.
Keywords: apol1; renal diseases; expression apol1; cell death ... See more keywords
Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019080829
Abstract: BACKGROUND APOL1 is found in human kidney podocytes and endothelia. Variants G1 and G2 of the APOL1 gene account for the high frequency of nondiabetic CKD among African Americans. Proposed mechanisms of kidney podocyte cytotoxicity… read more here.
Keywords: apol1; plasma membrane; endoplasmic reticulum; surface ... See more keywords
DGAT2 Inhibition Potentiates Lipid Droplet Formation to Reduce Cytotoxicity in APOL1 Kidney Risk Variants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2021050723
Abstract: Background Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry are major contributors to the large racial disparity in rates of human kidney disease. We previously demonstrated that… read more here.
Keywords: lipid droplet; risk; apol1; kidney ... See more keywords