Effect of APOL1 disease risk variants on APOL1 gene product
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DOI: 10.1042/bsr20160531
Abstract: Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution… read more here.
Keywords: risk; disease; apol1 variants; apol1 ... See more keywords
APOL1 variants may induce HIV-associated nephropathy during HIV primary infection
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DOI: 10.1093/jac/dkw563
Abstract: HIV-associated nephropathy (HIVAN) is still associated with high mortality, and is usually a late complication of HIV chronic infection. Since 2010, a link has been strongly established between APOL1 genetic variants and HIVAN, especially in… read more here.
Keywords: associated nephropathy; hiv; infection; variants may ... See more keywords
APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8.
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DOI: 10.1172/jci.insight.92581
Abstract: APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses or… read more here.
Keywords: protein; protein vamp8; apol1 variants; apol1 ... See more keywords