Structural analysis of a natural apolipoprotein A-I variant (L60R) associated with amyloidosis.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108347
Abstract: The reason that determines the pathological deposition of human apolipoprotein A-I variants inducing organ failure has been under research since the early description of natural mutations in patients. To shed light into the events associated… read more here.
Keywords: variant; analysis natural; structural analysis; apolipoprotein ... See more keywords
Apolipoprotein mediates soft-shelled turtle systemic septicemia spherical virus (STSSSV) infection
Sign Up to like & getrecommendations! Published in 2017 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2017.03.022
Abstract: Abstract Soft-shelled turtle systemic septicemia spherical virus (STSSSV) is a devastating pathogen of farmed Pelodiscus sinensis and causes great economic losses. Little is known about the pathogenic mechanisms of this virus. In this study, STSSSV… read more here.
Keywords: turtle systemic; soft shelled; shelled turtle; apolipoprotein ... See more keywords
Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner
Sign Up to like & getrecommendations! Published in 2017 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2017.08.025
Abstract: There is a critical gap in our knowledge of the mechanisms that govern interactions between daily life experiences (e.g., stress) and metabolic diseases, despite evidence that stress can have profound effects on cardiometabolic health. Apolipoprotein… read more here.
Keywords: manner; apolipoprotein constrains; stress; constrains hpa ... See more keywords
APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05802-2
Abstract: Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and… read more here.
Keywords: apoe genotype; plasma; plasma fatty; metabolic syndrome ... See more keywords
Lack of Influence of Apolipoprotein E Status on Cognition or Brain Structure in Professional Fighters.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurotrauma"
DOI: 10.1089/neu.2016.4453
Abstract: The role of the apolipoprotein e4 allele in moderating cognitive and neuroanatomical degeneration following repeated traumatic brain injury is controversial. Here we sought to establish the presence or absence of such a moderating relationship in… read more here.
Keywords: apolipoprotein; lack influence; influence apolipoprotein; brain ... See more keywords
Plasma apolipoprotein-B is an important risk factor for cardiovascular disease, and its assessment should be routine clinical practice.
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000476
Abstract: DOI:10.1097/MOL.0000000000000476 Although the causal relationship between apolipoprotein-B (apoB) containing lipoproteins, particularly LDL, and atherosclerotic vascular disease has been amply reinforced by recent trials [1 & ], interventions to raise HDL have proved ineffective in lowering… read more here.
Keywords: hdl cholesterol; risk; disease; cardiovascular disease ... See more keywords
Apolipoprotein E favours the blunting by high‐fat diet of prostacyclin receptor activation in the mouse aorta
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14386
Abstract: NO‐mediated, endothelium‐dependent relaxations of isolated arteries are blunted by ageing and high‐fat diets, as well as by apolipoprotein E deletion. The present study was designed to test the hypothesis that apolipoprotein E deletion impairs endothelium‐dependent… read more here.
Keywords: receptor activation; prostacyclin receptor; high fat; apolipoprotein ... See more keywords
Apolipoprotein A-I Inhibits Transendothelial Transport of Apolipoprotein B-Carrying Lipoproteins and Enhances Its Associated High-Density Lipoprotein Formation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Vascular Research"
DOI: 10.1159/000525259
Abstract: Caveola-located scavenger receptor type B class I (SR-BI) and activin receptor-like kinase-1 (ALK1) are involved in transendothelial transport of apolipoprotein B-carrying lipoproteins (apoB-LPs). Transport of apoB-LPs though mouse aortic endothelial cells (MAECs) is associated with… read more here.
Keywords: apoai; transport; apolipoprotein; apob lps ... See more keywords
Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/20406223221081605
Abstract: Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and ApoE4) and heterozygous carriers of the ε4 allele of the gene… read more here.
Keywords: apolipoprotein; disease; apoe; apoe fragments ... See more keywords
Association of lowering apolipoprotein B with cardiovascular outcomes across various lipid-lowering therapies: Systematic review and meta-analysis of trials
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Preventive Cardiology"
DOI: 10.1177/2047487319871733
Abstract: Aims The effect of therapeutic lowering of apolipoprotein B (apoB) on mortality and major adverse cardiovascular events is uncertain. It is also unclear whether these potential effects vary by different lipid-lowering strategies. Methods A total… read more here.
Keywords: association lowering; mortality; meta; lipid lowering ... See more keywords
Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes
Sign Up to like & getrecommendations! Published in 2017 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-017-0497-3
Abstract: BackgroundAbnormal lipid metabolism may contribute to an increase in endoplasmic reticulum (ER) stress, resulting in the pathogenesis of non-alcoholic steatohepatitis. Apolipoprotein A-I (apoA-I) accepts cellular free cholesterol and phospholipids transported by ATP-binding cassette transporter A1… read more here.
Keywords: overexpression; endoplasmic reticulum; reticulum stress; stress ... See more keywords