Dietary flaxseed oil improved western-type diet-induced atherosclerosis in apolipoprotein-E knockout mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.11.031
Abstract: Abstract Flaxseed oil is a rich source of n-3 fatty acid alpha-linolenic acid which has been identified as having significant cardioprotective effects. The objective of this study was to investigate the effect of partial replacement… read more here.
Keywords: western type; flaxseed oil; knockout mice; apolipoprotein knockout ... See more keywords
Mechanistic insights on the effect of crocin, an active ingredient of saffron, on atherosclerosis in apolipoprotein E knockout mice
Sign Up to like & getrecommendations! Published in 2022 at "Coronary Artery Disease"
DOI: 10.1097/mca.0000000000001142
Abstract: Background We investigated the effect of crocin treatment on atherosclerosis and serum lipids in apolipoprotein E knockout (ApoE−/−) mice, focusing on the expression of endothelial nitric oxide synthase (eNOS) and hypoxia-induced factor-1 alpha (HIF-1α). Methods… read more here.
Keywords: effect crocin; apolipoprotein knockout; expression; crocin ... See more keywords
2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice
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DOI: 10.3390/biom12091205
Abstract: 2-Hydroxypropyl-beta-cyclodextrin (2HPβCD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic cardiovascular disease. However,… read more here.
Keywords: regression; apolipoprotein knockout; beta cyclodextrin; lesion ... See more keywords
Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in apolipoprotein E Knockout Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24086956
Abstract: Despite the availability and use of numerous cholesterol-lowering drugs, atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality globally. Many researchers have focused their effort on identifying modified lipoproteins. However, lipid moieties such as… read more here.
Keywords: lpc cer; apolipoprotein knockout; untargeted lipidomic; cer ... See more keywords