A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.309275
Abstract: Objective— Type 1 diabetes mellitus (T1D) patients have an increased risk of cardiovascular disease despite high levels of high-density lipoproteins (HDL). Apolipoprotein M (apoM) and its ligand sphingosine 1-phospate (S1P) exert many of the anti-inflammatory… read more here.
Keywords: apom s1p; hdl particles; light hdl; hdl ... See more keywords
Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-019-1263-4
Abstract: BackgroundIn spite of the important role of Apolipoprotein-M (ApoM) and Sphingosine-1-Phosphate (S1P) played in atherosclerosis (AS), there was few related research reporting ApoM and S1P complex (ApoM-S1P) on biological activities of human umbilical vein endothelial… read more here.
Keywords: apom s1p; inflammation; pi3k akt; huvecs ... See more keywords
HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium
Sign Up to like & getrecommendations! Published in 2017 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-017-0429-2
Abstract: BackgroundHigh-density Lipoprotein (HDL) attenuates endothelial cell apoptosis induced by different cell-death stimuli such as oxidation or growth factor deprivation. HDL is the main plasma carrier of the bioactive lipid sphingosine 1-phosphate (S1P), which it is… read more here.
Keywords: apom s1p; anti apoptotic; hdl; sphingosine phosphate ... See more keywords
[The role of apolipoprotein M and sphingosine 1-phosphate axis in the prevention of atherosclerosis].
Sign Up to like & getrecommendations! Published in 2018 at "Orvosi hetilap"
DOI: 10.1556/650.2018.30980
Abstract: Previous studies showed that plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to risk of cardiovascular diseases. However, in the last few decades it became obvious that beyond its plasma level, HDL structure… read more here.
Keywords: sphingosine phosphate; apom s1p; role apolipoprotein; hdl ... See more keywords