Pharmacokinetics and Comparative Bioavailability of Apomorphine Sublingual Film and Subcutaneous Apomorphine Formulations in Patients with Parkinson’s Disease and “OFF” Episodes: Results of a Randomized, Three-Way Crossover, Open-Label Study
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DOI: 10.1007/s40120-021-00251-6
Abstract: In a pivotal study, apomorphine sublingual film (APL; KYNMOBI®) was an effective and generally well-tolerated on-demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD), approved across the dose range of 10–30 mg. Pharmacokinetics… read more here.
Keywords: bioavailability; apo apo; apomorphine formulations; open label ... See more keywords
Medial prefrontal cortex ERK and conditioning: Evidence for the association of increased medial prefrontal cortex ERK with the presence/absence of apomorphine conditioned behavior using a unique post-trial conditioning/extinction protocol
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DOI: 10.1016/j.bbr.2019.02.022
Abstract: &NA; Increases in medial prefrontal cortex ERK have been linked to learning and memory processes. In the present study separate groups of rats initially underwent testing in an open‐field paired with either 2.0 mg/kg apomorphine… read more here.
Keywords: medial prefrontal; apomorphine; response; post trial ... See more keywords
An evaluation of subcutaneous apomorphine for the treatment of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1787379
Abstract: ABSTRACT Introduction Heterogeneity of symptoms and individual variability of progression characterizes Parkinson’s disease. Unmet therapeutic needs include a cure, disease modification, and improvement of available marketed dopamine-substituting compounds. Personalized treatment, tailored to the patients’ needs… read more here.
Keywords: treatment; disease; motor; subcutaneous apomorphine ... See more keywords
Induction of emesis with apomorphine using a novel gingival administration method in dogs.
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DOI: 10.1111/vec.13115
Abstract: OBJECTIVE To describe a novel method of inducing emesis in the dog using gingival administration of apomorphine, compare the efficacy of inducing emesis with gingival apomorphine to conjunctival apomorphine, and describe adverse effects associated with… read more here.
Keywords: administration; gingival administration; method; induction emesis ... See more keywords
Sublingual apomorphine therapy as an alternative to complex continuous infusion pumps in advanced Parkinson's disease treatment: a district nurse-led intervention.
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DOI: 10.12968/bjcn.2022.27.7.328
Abstract: In the UK, Parkinson's disease (PD) is estimated to affect an annual incidence of 15-20 per 100 000 of the population over the age of 60. Service users living with advanced-stage PD require the use… read more here.
Keywords: district nurse; apomorphine; apomorphine therapy; parkinson disease ... See more keywords
Looking Beyond the Fog—Apomorphine Demystified
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DOI: 10.4103/aian.aian_19_20
Abstract: We acknowledge the points made by the esteemed author. As pointed our thoughts to the observations are as below: 1. Apomorphine is a well-accepted and established therapy in moderate to advanced Parkinson’s disease both as… read more here.
Keywords: therapy; apomorphine; response; paper ... See more keywords