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   Articles with "apoptosis" as a keyword



Depletion of cdc‐25.3, a Caenorhabditis elegans orthologue of cdc25, increases physiological germline apoptosis

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recommendations! Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12717

Abstract: In Caenorhabditis elegans hermaphrodites, physiological germline apoptosis is higher in cdc‐25.3 mutants than in wild‐type. The elevated germline apoptosis in cdc‐25.3 mutants seems to be induced by accumulation of double‐stranded DNA breaks (DSBs). Both DNA… read more here.

Keywords: germline apoptosis; apoptosis; cdc mutants; caenorhabditis elegans ... See more keywords

Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2.

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recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.13032

Abstract: Chronic kidney disease (CKD) is a common and complex disease in kidneys which has been associated with an increased risk of renal cell carcinoma (RCC). Elevated homocysteine (Hcy) levels are known to influence the development… read more here.

Keywords: apoptosis; mir; 1929 expression; dnmt1 ezh2 ... See more keywords

STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13584

Abstract: Calcium is a ubiquitous messenger that regulates a wide range of cellular functions, but its involvement in the pathophysiology of acute myeloid leukemia (AML) is not widely investigated. Here, we identified, from an analysis of… read more here.

Keywords: cell cycle; cell; malignant monocytic; normal malignant ... See more keywords

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

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recommendations! Published in 2025 at "Molecular Oncology"

DOI: 10.1002/1878-0261.70002

Abstract: Chondrosarcomas are common bone sarcomas frequently resistant to radiation and chemotherapy, with high recurrence rates, development of metastatic disease, and death. Fibrosarcomas are soft tissue sarcomas associated with poor outcomes. Translocase of outer mitochondrial membrane… read more here.

Keywords: cancer; resistance; tomm20; cancer aggressiveness ... See more keywords

Estrogen inhibits starvation‐induced apoptosis in osteocytes by a redox‐independent process involving association of JNK and glutathione S‐transferase P1‐1

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12216

Abstract: Estrogen deficiency causes bone loss as a result of microdamage, oxidative stress, and osteocyte apoptosis. A relationship between oxidative stress‐induced apoptosis, c‐Jun N‐terminal kinase (JNK) activation, and expression of factors involved in bone remodeling has… read more here.

Keywords: starvation induced; apoptosis; jnk; induced apoptosis ... See more keywords

Suppressed de novo lipogenesis by plasma membrane citrate transporter inhibitor promotes apoptosis in HepG2 cells

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recommendations! Published in 2018 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12435

Abstract: Suppression of the expression or activities of enzymes that are involved in the synthesis of de novo lipogenesis (DNL) in cancer cells triggers cell death via apoptosis. The plasma membrane citrate transporter (PMCT) is the… read more here.

Keywords: citrate; apoptosis; hepg2 cells; pmcti ... See more keywords

XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12655

Abstract: Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) that frequently results in renal disease, and is characterized by a variety of symptoms, including albuminuria. It has been shown that apoptosis of glomerular mesangial… read more here.

Keywords: pten akt; apoptosis; oxidative stress; cell apoptosis ... See more keywords
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NGF protects neuroblastoma cells against β‐amyloid‐induced apoptosis via the Nrf2/HO‐1 pathway

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12742

Abstract: As one of the main neurotrophic factors, nerve growth factor (NGF) participates in various processes related to viability, plasticity, and neuronal growth. NGF is known to protect against cell death and toxicity triggered by β‐amyloid… read more here.

Keywords: protects neuroblastoma; ngf protects; apoptosis; jnk jun ... See more keywords

Dexamethasone promotes mesenchymal stem cell apoptosis and inhibits osteogenesis by disrupting mitochondrial dynamics

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12771

Abstract: Long‐term or heavy use of glucocorticoids can cause severe necrosis of the femoral head, but the underlying mechanisms are still unclear. Recent studies have found that mitochondrial dynamics play an important role in femoral head… read more here.

Keywords: apoptosis; mitochondrial dynamics; dexamethasone; cell ... See more keywords
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Paclitaxel induces apoptosis through the TAK1–JNK activation pathway

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12917

Abstract: Paclitaxel (PTX) has previously been used to treat tumours of various tissue origins, such as lung, breast, ovarian, prostate cancers and leukemia. PTX‐induced apoptosis is associated with p38 mitogen‐activated protein kinase (p38 MAPK), extracellular signal‐regulated… read more here.

Keywords: apoptosis; jnk; cleavage; tak1 ... See more keywords

Nitric oxide inhibits endothelial cell apoptosis by inhibiting cysteine‐dependent SOD1 monomerization

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13362

Abstract: Endothelial cell apoptosis is an important pathophysiology in many cardiovascular diseases. The gasotransmitter nitric oxide (NO) is known to regulate cell survival and apoptosis. However, the mechanism underlying the effect of NO remains unclear. In… read more here.

Keywords: apoptosis; cell apoptosis; sod1 monomerization; endothelial cell ... See more keywords