GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173495
Abstract: GDF11 has been reported to play a critical role in rejuvenating hypertrophy heart, skeletal muscle, and blood vessel regeneration in aged mice. Whether GDF11 can regulate autophagy in cardiomyocytes remains largely unknown. Thus, the purpose… read more here.
Keywords: replenishment protects; apoptosis cardiomyocytes; gdf11 replenishment; apoptosis ... See more keywords
Knockdown of lncRNA Abhd11os attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis in cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001074
Abstract: ABSTRACT Long non-coding RNA (lncRNA) is one potential target for the treatment of various disorders. Here, we explored the role of Abhd11os in ischemia/reperfusion-induced myocardial injury, and preliminarily explored the regulatory mechanisms. Relative Abhd11os expression… read more here.
Keywords: apoptosis cardiomyocytes; abhd11os; ischemia reperfusion; apoptosis ... See more keywords
Macrophage-Derived Exosomes in TLR9−/− Mice Ameliorate Sepsis-Induced Mitochondrial Oxidative Stress and Apoptosis in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5719974
Abstract: Objective To explore the mechanisms of TLR9 from macrophages on mitochondrial apoptosis in cardiomyocytes at early stage of sepsis. Methods The in vivo and in vitro sepsis mice were bone marrow transplantation (BMT) with wild… read more here.
Keywords: sepsis; apoptosis cardiomyocytes; oxidative stress; tlr9 macrophages ... See more keywords
Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling
Sign Up to like & getrecommendations! Published in 2019 at "Biological Research"
DOI: 10.1186/s40659-019-0265-0
Abstract: BackgroundOur previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI). This study aims to explore whether MALAT1 enhanced cardiomyocyte… read more here.
Keywords: apoptosis cardiomyocytes; apoptosis; rna; mtor signaling ... See more keywords