lncRNA‐CIR regulates cell apoptosis of chondrocytes in osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27997
Abstract: Osteoarthritis (OA) is a complex chronic degenerative joint disease involving oxidative stress, inflammation, and apoptosis of chondrocytes. As decoys of micro RNAs, long non‐coding RNAs (lncRNAs) play important roles in various biological processes. This study… read more here.
Keywords: apoptosis chondrocytes; regulates cell; lncrna cir; apoptosis ... See more keywords
Galectin‐3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR‐4‐mediated oxidative stress pathway in TC28a2 human chondrocyte cells
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23414
Abstract: Osteoarthritis (OA) is a common degenerative joint disease. The pathological changes of chondrocytes involve oxidative stress, the pro‐inflammatory response, and pro‐apoptotic events. Galectin‐3 (Gal‐3) is a 35 kDa protein with a special chimeric structure. Gal‐3 participates… read more here.
Keywords: chondrocyte; tc28a2 human; human chondrocyte; oxidative stress ... See more keywords
ERK1/2-Mediated Activation of DRP1 Regulates Mitochondrial Dynamics and Apoptosis in Chondrocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.11.003
Abstract: OBJECTIVE To determine the Dynamin-related protein 1 (DRP1) regulation of mitochondrial fission in chondrocytes under pathological conditions, an area which is underexplored in osteoarthritis pathogenesis. DESIGN DRP1 protein expression was determined by IHC or IF… read more here.
Keywords: apoptosis chondrocytes; erk1 mediated; apoptosis; expression ... See more keywords
Long non-coding RNA plasmacytoma variant translocation 1 and growth arrest specific 5 regulate each other in osteoarthritis to regulate the apoptosis of chondrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2063653
Abstract: ABSTRACT Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and growth arrest specific 5 (GAS5) have opposite functions in the apoptosis of chondrocytes, which are involved in the pathogenesis of osteoarthritis (OA). The opposite… read more here.
Keywords: pvt1 gas5; apoptosis chondrocytes; gas5; regulate ... See more keywords
Oligomeric proanthocyanidins inhibit apoptosis of chondrocytes induced by interleukin-1β.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7124
Abstract: Oligomeric proanthocyanidin (OPC) is a water-soluble plant polyphenolic compound known for its cytoprotective effects in various tissue types. However, its effect on chondrocytes has not been well characterized. The present study aimed to investigate the… read more here.
Keywords: apoptosis chondrocytes; induced apoptosis; chondrocytes induced; opc ... See more keywords
Excessive mechanical stretch-mediated osteoblasts promote the catabolism and apoptosis of chondrocytes via the Wnt/β-catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12232
Abstract: Excessive biomechanical loading is considered an important cause of osteoarthritis. Although the mechanical responses of chondrocytes and osteoblasts have been investigated, their communication during mechanical loading and the underlying molecular mechanisms are not yet fully… read more here.
Keywords: apoptosis chondrocytes; mechanical stretch; apoptosis; catenin signaling ... See more keywords