Boosting Tumor Apoptosis and Ferroptosis with Multienzyme Mimetic Au Single‐Atom Nanozymes Engaged in Cascade Catalysis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202412767
Abstract: Nanozyme‐based catalytic therapy has garnered much attention in cancer treatment for converting endogenous substrates into reactive oxygen species (ROS), which induce oxidative stress damage in tumors. However, the effectiveness of nanozymes is hindered by the… read more here.
Keywords: apoptosis ferroptosis; tumor apoptosis; single atom; catalysis ... See more keywords
Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23467
Abstract: Exposure to nickel oxide nanoparticles (NiONPs), which have been widely produced and applied in industry, leads to adverse pulmonary and systemic effects. The aim of this study is to investigate the involvement of apoptosis and… read more here.
Keywords: apoptosis ferroptosis; nickel oxide; lung; oxide nanoparticles ... See more keywords
Andrographolide drives dual apoptosis and ferroptosis via caspase-3 and FACL4 in T-ALL cell lines
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Hematology"
DOI: 10.1007/s12185-025-04044-7
Abstract: This study investigated the anti-tumor effects of andrographolide, a diterpene lactone derived from Andrographis paniculata, on T-cell acute lymphoblastic leukemia (T-ALL) cells. Andrographolide induced dose-dependent cytotoxicity and morphological changes in the T-ALL cell line Jurkat… read more here.
Keywords: apoptosis ferroptosis; andrographolide drives; ferroptosis; cell ... See more keywords
Polypyrrole-iron phosphate-glucose oxidase-based nanocomposite with cascade catalytic capacity for tumor synergistic apoptosis-ferroptosis therapy
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.131671
Abstract: Abstract Utilizing the synergistic effect of apoptosis and ferroptosis for tumor elimination is a promising and effective strategy. Herein, a novel PPy-FePO-GOx-PVA nanocomposite with cascade catalytic capacity was designed and fabricated for tumor synergistic apoptosis-ferroptosis… read more here.
Keywords: apoptosis ferroptosis; cascade catalytic; apoptosis; tumor ... See more keywords
Phosphorescent rhenium(I) complexes conjugated with artesunate: Mitochondrial targeting and apoptosis-ferroptosis dual induction.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111537
Abstract: Cell death is essential for cancer, which can be induced through multiple mechanisms. Ferroptosis, a newly emerging form of non-apoptotic cell death, involves the generation of iron-dependent reactive oxygen species (ROS). In this study, we… read more here.
Keywords: rhenium complexes; ferroptosis; art; phosphorescent rhenium ... See more keywords
Vildagliptin improves neurological function by inhibiting apoptosis and ferroptosis following intracerebral hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136579
Abstract: Intracerebral hemorrhage (ICH) is a fatal health problem which lacks effective treatment. The apoptosis caused by hematoma constituents, and the ferroptosis due to iron overload, are prominent contributors of neurologic impairment after ICH. Targeting cell… read more here.
Keywords: ferroptosis; vilda; ferroptosis following; apoptosis ferroptosis ... See more keywords
Reactive Oxygen Species Amplifier for Apoptosis-Ferroptosis Mediated High-Efficiency Radiosensitization of Tumors.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c01625
Abstract: Insufficient reactive oxygen species (ROS) production and radioresistance have consistently contributed to the failure of radiotherapy (RT). The development of a biomaterial capable of activating ROS-induced apoptosis and ferroptosis is a potential strategy to enhance… read more here.
Keywords: apoptosis ferroptosis; reactive oxygen; oxygen species; ferroptosis ... See more keywords
Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2036909
Abstract: The study aimed to explore the effects of local anesthetic bupivacaine on bladder cancer cells in vivo and in vitro. The cytotoxicity was detected by MTT assay. Apoptosis was measured by Hoechst 33342 staining and… read more here.
Keywords: apoptosis ferroptosis; bupivacaine; bladder cancer; pi3k akt ... See more keywords
Organelle-Specific Mechanisms in Crosstalk between Apoptosis and Ferroptosis
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/3400147
Abstract: Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of regulated cell death that involves iron-dependent accumulations of lipid hydroperoxides. While these two cell death mechanisms were initially believed to be mutually… read more here.
Keywords: organelle specific; apoptosis; crosstalk apoptosis; apoptosis ferroptosis ... See more keywords
AURKB inhibition induces rhabdomyosarcoma apoptosis and ferroptosis through NPM1/SP1/ACSL5 axis
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.182429
Abstract: Rhabdomyosarcoma (RMS) is one of the most common solid tumors in children and adolescents. Patients with relapsed/refractory RMS have limited treatment options, highlighting the urgency for the identification of novel therapeutic targets for RMS. In… read more here.
Keywords: npm1 sp1; apoptosis ferroptosis; inhibition; ferroptosis ... See more keywords
Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress
Sign Up to like & getrecommendations! Published in 2023 at "Integrative Cancer Therapies"
DOI: 10.1177/15347354231172117
Abstract: Background: Cisplatin is a widely used anticancer drug in clinic, but it has a damaging effect on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had a alleviating effect on cisplatin toxicity.… read more here.
Keywords: oxidative stress; apoptosis ferroptosis; muscle; cisplatin ... See more keywords