Pentoxifylline induces apoptosis of HepG2 cells by reducing reactive oxygen species production and activating the MAPK signaling
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.05.029
Abstract: Aims: Pentoxifylline (PTX) is a methylxanthine derivative and has potent anti‐tumor activity. This study aimed at investigating the anti‐HCC effects of PTX and associated molecular mechanisms. Main methods: The effects of varying doses of PTX… read more here.
Keywords: reactive oxygen; production; hepg2 cells; apoptosis hepg2 ... See more keywords
6-OHBDE-47 induces transcriptomic alterations of CYP1A1, XRCC2, HSPA1A, EGR1 genes and trigger apoptosis in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.03.007
Abstract: In this study, HepG2 cells were exposed to 6-hydroxy- 2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE-47) for 3 and 6 days for monitoring cytotoxic effects and alterations in its transcriptomic profile. MTT assay showed that cells exposed to 6-OH-BDE-47 (50 nM)… read more here.
Keywords: ohbde induces; cells exposed; hepg2 cells; apoptosis hepg2 ... See more keywords
Silver Nanoparticles Induce Apoptosis in HepG2 Cells through Particle-Specific Effects on Mitochondria.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c08246
Abstract: Silver nanoparticles (AgNPs) have been widely used in biomedical and consumer products. It remains challenging to distinguish the toxicity of AgNPs derived from the particle form or the released silver ions (Ag+). In this study,… read more here.
Keywords: apoptosis; cells particle; silver nanoparticles; apoptosis hepg2 ... See more keywords
Cytisine induces apoptosis of HepG2 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6991
Abstract: Cytisine is a quinolizidine alkaloid, which has been reported to be among the major bioactive components of Sophora alopecuraides L. Quinolizidine alkaloids have previously been demonstrated to inhibit the proliferation of several types of tumor cells.… read more here.
Keywords: cytisine; hepg2 cells; caspase; apoptosis hepg2 ... See more keywords
Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10705
Abstract: Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor that has demonstrated clinical activity against various solid tumors. The aim of the present study was to explore the effects of SAHA on the apoptosis of… read more here.
Keywords: acetylation; endoplasmic reticulum; hepg2 cells; apoptosis hepg2 ... See more keywords