Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.071
Abstract: Meagre and suboptimal therapeutic response along with the side effect profile associated with the existing anticancer therapy have necessitated the development of new therapeutic modalities to curb this disease. Bearing in mind the current scenario,… read more here.
Keywords: anti inflammatory; cell lines; apoptosis inducing; unveiling novel ... See more keywords
Synthesis, 18F-radiolabeling and apoptosis inducing studies of novel 4, 7-disubstituted coumarins.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103663
Abstract: In present study, a new series of 4, 7-disubstituted coumarin derivatives (7a-y) have been synthesized as galectin-1 targeting apoptosis inducing agents and evaluated for their in vitro cytotoxic potentials against a panel of selected human… read more here.
Keywords: apoptosis inducing; apoptosis; cell lines; novel disubstituted ... See more keywords
Understanding the Dr. Jekyll and Mr. Hyde nature of apoptosis-inducing factor: future perspectives
Sign Up to like & getrecommendations! Published in 2017 at "Biomedical Journal"
DOI: 10.1016/j.bj.2017.06.004
Abstract: Apoptosis-inducing factor (AIF) is emerging as a key protein in regulation of basic physiological processes including phagocytosis, mitophagy and regulation of the redox state. Recent evidences suggest that the enzymatic activity of AIF may play… read more here.
Keywords: understanding jekyll; apoptosis inducing; inducing factor; nature ... See more keywords
Copper based metallonucleases as potential antitumor drugs: Synthesis, Structure, in vitro Cytotoxicity and Apoptosis inducing properties
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130278
Abstract: Abstract The new polypyridyl ligands L1 and L2 {L1 =4,4′-oxybis(N,N-bis(pyridin- 2-ylmethyl)aniline); L2 = 4-methyl-N, N-bis(pyridin- 2-ylmethyl)aniline} and three relevant di-, mono-nucleating Cu(II) complexes [Cu2L1Cl4]2 (1), [CuL2Cl2]2•4H2O (2) and [Cu2(L2)2(μ-Cl)2] (ClO4)2 (3) have been synthesized as anticancer agents.… read more here.
Keywords: cytotoxicity; structure; apoptosis inducing; copper based ... See more keywords
Coumarins from Juglans Mandshurica Maxim and their apoptosis-inducing activities in hepatocarcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2018.01.005
Abstract: Abstract Phytochemical investigation of the bark of Juglans mandshurica led to the isolation of two new coumarins, juglansoside A–B (1–2), along with five known compounds (3–7). The structures of new compounds were elucidated by comprehensive… read more here.
Keywords: apoptosis inducing; apoptosis; mandshurica maxim; coumarins juglans ... See more keywords
Lactobacilli enhance reactive oxygen species-dependent apoptosis-inducing signaling
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.01.015
Abstract: H2O2-producing lactobacilli in the vaginal fluid have been suggested to play a potential tumor-preventive role in addition to the control of undesirable microorganisms. As the vaginal fluid also contains a significant concentration of peroxidase that… read more here.
Keywords: apoptosis inducing; lactobacilli enhance; malignant cells; apoptosis ... See more keywords
Apoptosis-inducing effects of Terminalia phanerophlebia leaf extracts on human renal cells
Sign Up to like & getrecommendations! Published in 2021 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2021.03.009
Abstract: Abstract The study investigated the toxicogenic effects and molecular mechanisms of Terminalia phanerophlebia on human renal cells. The methylthiazol tetrazolium (MTT) assay was used to assess the cytotoxicity of a crude leaf extract of Terminalia… read more here.
Keywords: human renal; terminalia phanerophlebia; renal cells; apoptosis inducing ... See more keywords
Apoptosis inducing properties of 3-biotinylate-6-benzimidazole B-nor-cholesterol analogues
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DOI: 10.1016/j.steroids.2021.108822
Abstract: In this work, a series of Biotin-substituted B-nor-cholesteryl benzimidazole compounds were synthesized. The antiproliferativeactivities of these compounds were evaluated in vitro using a series of human cancer cell lines, including HeLa (cervical cancer), SKOV3(ovarian cancer),… read more here.
Keywords: biotinylate benzimidazole; apoptosis inducing; inducing properties; cancer ... See more keywords
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00777
Abstract: Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. Starting from AIF(370-394), we report the… read more here.
Keywords: cypa; apoptosis inducing; inducing factor; cell death ... See more keywords
Umbelliferone–oxindole hybrids as novel apoptosis inducing agents
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c7nj02578e
Abstract: In furtherance of our endeavour towards the synthesis of novel bioactive agents, a panel of (E)-3-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)indolin-2-one derivatives were synthesized using diverse 5-substituted oxindoles and 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde (3a). These synthesized analogues were further evaluated for their in… read more here.
Keywords: novel apoptosis; umbelliferone oxindole; apoptosis inducing; apoptosis ... See more keywords
Synthesis, anti-proliferative and apoptosis-inducing studies of palladacycles containing a diphosphine and a Sn,As-based chelate ligand.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c8dt03875a
Abstract: Cleavage of the bromide bridges in [Pd2(μ-Br)2{κ2(Sn,As)-2-MeBrSnC6F4AsPh2}2] (1) by diphosphine ligands gave the mono- and dinuclear palladacycles [Pd(L)Br{κ2(Sn,As)-2-MeBrSnC6F4AsPh2}] [L = dppe (2) dppm (3), ortho-dppBz (4)] and [Pd2Br2(para-dppBz){κ2(Sn,As)-2-MeBrSnC6F4AsPh2}2] (5). The interactions of these complexes with… read more here.
Keywords: anti proliferative; apoptosis inducing; proliferative apoptosis; synthesis anti ... See more keywords