Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.098
Abstract: A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell… read more here.
Keywords: induction effects; dna damage; bis pyrazole; pyrazole derivatives ... See more keywords
Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10525-1
Abstract: During thymic negative selection, autoreactive thymocytes carrying T cell receptor (TCR) with overtly strong affinity to self-MHC/self-peptide are removed by Bim-dependent apoptosis, but how Bim is specifically regulated to link TCR activation and apoptosis induction… read more here.
Keywords: negative selection; thymic negative; apoptosis induction; apoptosis ... See more keywords
Influenza A virus NS1 protein‐induced JNK activation and apoptosis are not functionally linked
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Microbiology"
DOI: 10.1111/cmi.12721
Abstract: Expression of the influenza A virus (IAV) nonstructural protein (NS1) results in the activation of c‐Jun N‐terminal kinase (JNK). Both NS1 and JNK are involved in apoptosis induction. To investigate their interrelationship, we stably expressed… read more here.
Keywords: jnk; apoptosis; activation; virus ... See more keywords
Apoptosis induction in K562 human myelogenous leukaemia cells is connected to the modulation of Wnt/β‐catenin signalling by BHX, a novel pyrazoline derivative
Sign Up to like & getrecommendations! Published in 2018 at "Cell Proliferation"
DOI: 10.1111/cpr.12433
Abstract: The goal of this study was to explore the effects of BHX on human chronic myeloid leukaemia (CML) cells and to elucidate the underlying molecular mechanism. read more here.
Keywords: k562 human; myelogenous leukaemia; induction k562; human myelogenous ... See more keywords
Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal–Derived Endophytic Fungus Aspergillus sp.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.542891
Abstract: The endophytic fungal community in the marine ecosystem has been demonstrated to be relevant source of novel and pharmacologically active secondary metabolites. The current study focused on the evaluation of cytotoxic and apoptosis induction potential… read more here.
Keywords: cytotoxic; secondary metabolites; culture; cytotoxicity ... See more keywords
Effective Cellular Transport of Ortho-Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21072389
Abstract: Metformin is a substrate for plasma membrane monoamine transporters (PMAT) and organic cation transporters (OCTs); therefore, the expression of these transporters and interactions between them may affect the uptake of metformin into tumor cells and… read more here.
Keywords: mcf; apoptosis induction; antiproliferative activity; mcf cells ... See more keywords
Cytotoxic Effects of Darinaparsin, a Novel Organic Arsenical, against Human Leukemia Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032282
Abstract: To explore the molecular mechanisms of action underlying the antileukemia activities of darinaparsin, an organic arsenical approved for the treatment of peripheral T–cell lymphoma in Japan, cytotoxicity of darinaparsin was evaluated in leukemia cell lines… read more here.
Keywords: cytotoxic effects; leukemia; apoptosis induction; effects darinaparsin ... See more keywords