Targeting Apoptosis Inhibition to Activate Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.11.002
Abstract: A recent study by Rodriguez-Ruiz et al. suggests that inhibition of apoptotic caspases can augment radiation-induced antitumor immunity, independent of type I IFN. Their findings also highlight caspase-independent cytotoxicity in radiation therapy-induced antitumor immunity, proposing SLC7A2 as… read more here.
Keywords: immunity; antitumor immunity; targeting apoptosis; activate antitumor ... See more keywords
Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment.
Sign Up to like & getrecommendations! Published in 2017 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.6b00489
Abstract: A series of 2-sulfonyl-pyrimidinyl derivatives was developed as apoptosis inhibitors. These represent the first class of apoptosis inhibitors that function through stabilizing mitochondrial respiratory complex II. Starting from a phenotypic screen hit with micromolar activity,… read more here.
Keywords: sulfonyl pyrimidinyl; pyrimidinyl derivatives; apoptosis inhibition;
Apoptosis inhibition restrains primary malignant traits in different Drosophila cancer models
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1043630
Abstract: Tumor cells exploit multiple mechanisms to evade apoptosis, hence the strategies aimed at reactivating cell death in cancer. However, recent studies are revealing that dying cells play remarkable pro-oncogenic roles. Among the mechanisms promoting cell… read more here.
Keywords: death; cell; cancer; apoptosis inhibition ... See more keywords