Structural basis of BAK activation in mitochondrial apoptosis initiation
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27851-y
Abstract: BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK… read more here.
Keywords: apoptosis initiation; activation; bak; bak activation ... See more keywords
Metastability, an emerging concept governing BOK-mediated apoptosis initiation
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25801
Abstract: By regulating mitochondrial outer membrane permeabilization (MOMP), the rate-limiting event in caspase activation, BCL-2 family proteins are responsible for apoptosis initiation [1]. Most BCL-2 proteins obey canonical rules of mitochondrial apoptosis [2]. These rules define… read more here.
Keywords: bok mediated; apoptosis; apoptosis initiation; bcl ... See more keywords