Combination Lenalidomide/Bortezomib Treatment Synergistically Induces Calpain-Dependent Ikaros Cleavage and Apoptosis in Myeloma Cells
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DOI: 10.1158/1541-7786.mcr-19-0431
Abstract: Multiple myeloma had been successfully treated by combining lenalidomide and bortezomib with reports suggesting benefits of such a combination even in relapsed/refractory cases. Recently, it was demonstrated that Ikaros degradation by lenalidomide happens via proteasome-dependent… read more here.
Keywords: myeloma; lenalidomide bortezomib; combination; apoptosis myeloma ... See more keywords