Apoptosis oxidative damage‐mediated and antiproliferative effect of selenylated imidazo[1,2‐a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22663
Abstract: Imidazo[1,2‐a]pyridines (IP) and organoselenium compounds have been widely exploited in medicinal chemistry due to their pharmacological activities. Hepatocellular carcinoma (HCC) has few treatment options, and unfortunately, the prognosis is poor. Thus, the development of novel… read more here.
Keywords: hepatocellular carcinoma; cells vivo; apoptosis oxidative; hepg2 cells ... See more keywords
Apoptosis, oxidative stress and genotoxicity in developing zebrafish after aluminium exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2021.105872
Abstract: Aluminium is a non-essential metal and potentially toxic to organisms whose environmental concentration increases due to pollution. In our previous studies, the behavioral changes induced by aluminium were already shown on zebrafish, a model organism… read more here.
Keywords: apoptosis oxidative; aluminium; stress genotoxicity; concentration ... See more keywords
SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172516
Abstract: Angiotensin II (Ang II) is a vasoactive peptide that elevates arterial blood pressure and leads to hypertension. Ang II has been reported to induce endothelial dysfunction by induction of apoptosis and oxidative stress in vascular… read more here.
Keywords: apoptosis oxidative; vascular endothelial; induced apoptosis; endothelial cells ... See more keywords
Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107595
Abstract: Dipeptidyl-peptidase 3 (DPP3) plays a key role in regulating apoptosis, oxidative stress and inflammation under various pathological conditions, however, whether DPP3 regulates apoptosis and oxidative stress in neurons undergoing cerebral ischemia/reperfusion injury has not yet… read more here.
Keywords: apoptosis oxidative; dpp3; stress inflammation; oxidative stress ... See more keywords
AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.01.009
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking of curable treatments to date. Adeno-associated virus (AAV) vectors make gene therapy an effective strategy in treating neurological disorders. Despite Kaspar and colleagues have showed… read more here.
Keywords: apoptosis oxidative; cells apoptosis; tdp cells; expression ... See more keywords
LncRNA KCNQ1OT1 promotes apoptosis and oxidative stress of human lens epithelial cells through epigenetic regulation of WRN.
Sign Up to like & getrecommendations! Published in 2022 at "Current eye research"
DOI: 10.1080/02713683.2022.2026975
Abstract: PURPOSE Long non-coding RNA KCNQ1OT1 is fundamental to age-related cataract (ARC), whereas the underlying mechanism is still unknown. Here, we explored the possible mechanism of KCNQ1OT1 in ARC. METHODS The expression of KCNQ1OT1 in ARC… read more here.
Keywords: wrn; apoptosis oxidative; sra01 cells; oxidative stress ... See more keywords
TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
Sign Up to like & getrecommendations! Published in 2022 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2022.2081862
Abstract: OBJECTIVES This research aimed to dissect the function of TYRP1 and PMEL in glaucomatous animal and cell models. METHODS A chronic ocular hypertension (COH) rat model was induced in the right eyes of rats through… read more here.
Keywords: tyrp1; oxidative stress; apoptosis oxidative; pmel ... See more keywords
Treatment with melatonin and selenium attenuates docetaxel‐induced apoptosis and oxidative injury in kidney and testes of mice
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13320
Abstract: Docetaxel (DTX) has been used in cancer treatments for several decades, but it results in many adverse apoptotic effects through excessive production of reactive oxygen species (ROS) in some tissue including the kidney and testes.… read more here.
Keywords: apoptosis oxidative; dtx; induced apoptosis; kidney testes ... See more keywords
Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients
Sign Up to like & getrecommendations! Published in 2018 at "Liver International"
DOI: 10.1111/liv.13562
Abstract: Ursodeoxycholic acid (UDCA) is a secondary hydrophilic bile acid (BA) used as therapy for a range of hepatobiliary diseases. Its efficacy in non‐alcoholic fatty liver disease (NAFLD) is still under debate. Here, we aimed to… read more here.
Keywords: apoptosis oxidative; morbidly obese; ursodeoxycholic acid; stress morbidly ... See more keywords
Upregulated IGFBP3 with Aging Is Involved in Modulating Apoptosis, Oxidative Stress, and Fibrosis: A Target of Age-Related Erectile Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6831779
Abstract: Aging has been deemed the primary factor in erectile dysfunction (ED). Herein, age-related changes in the erectile response and histomorphology were detected, and the relationship between aging and ED was investigated based on gene expression… read more here.
Keywords: apoptosis; age related; erectile dysfunction; apoptosis oxidative ... See more keywords
Senegenin Inhibits Aβ1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via Activation of the PI3K/Akt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s346238
Abstract: Background/Aim Apoptosis and oxidative stress have been considered as key events in the pathogenesis of Alzheimer’s disease (AD). Senegenin (Sen), the major and most effective ingredient of Radix Polygalae, which has anti-apoptotic and anti-oxidative effects.… read more here.
Keywords: pi3k; stress; induced pc12; oxidative stress ... See more keywords