Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein.
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DOI: 10.1021/acs.jmedchem.1c01459
Abstract: We have recently reported on Lys-covalent agents that, based on aryl-sulfonyl fluorides, were designed to target binding site Lys 311 in the X-linked inhibitor of apoptosis protein (XIAP). Similar to XIAP, melanoma-IAP (ML-IAP), a less… read more here.
Keywords: iap; covalent; covalent antagonists; antagonists melanoma ... See more keywords
Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00467
Abstract: We have recently reported on the use of aryl-fluorosulfates in designing water- and plasma-stable agents that covalently target Lys, Tyr, or His residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP)… read more here.
Keywords: inhibitor apoptosis; lys covalent; protein iap; apoptosis protein ... See more keywords
Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.
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DOI: 10.1021/acs.jmedchem.8b01668
Abstract: Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of cancer cells. Inhibitor of apoptosis proteins (IAPs)… read more here.
Keywords: iap antagonists; apoptosis; protein iap; apoptosis protein ... See more keywords
Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity
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DOI: 10.1126/scisignal.aao3964
Abstract: The unique positioning of similar domains determines the signaling specificity of IAP family proteins. Structure-function specificity of IAP proteins Inhibitor of apoptosis proteins (IAPs) are involved in regulating cell death and inflammation. As such, both… read more here.
Keywords: protein; apoptosis; apoptosis protein; cell death ... See more keywords
Prediction of apoptosis protein subcellular location based on amphiphilic pseudo amino acid composition
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1157021
Abstract: Introduction: Apoptosis proteins play an important role in the process of cell apoptosis, which makes the rate of cell proliferation and death reach a relative balance. The function of apoptosis protein is closely related to… read more here.
Keywords: subcellular location; apoptosis; apoptosis protein; based amphiphilic ... See more keywords