In silico investigation of nonsynonymous single nucleotide polymorphisms in BCL2 apoptosis regulator gene to design novel protein‐based drugs against cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30330
Abstract: BCL2 apoptosis regulator gene encodes Bcl‐2 pro‐survival protein, which plays an important role to evade apoptosis in various cancers. Moreover, single nucleotide polymorphisms (SNPs) in the BCL2 gene can be nonsynonymous (nsSNPs), which might affect… read more here.
Keywords: apoptosis regulator; single nucleotide; bcl2 apoptosis; gene ... See more keywords
In silico identification of potential inhibitor for TP53-induced glycolysis and apoptosis regulator in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-021-02665-3
Abstract: Head and neck squamous cell carcinoma (HNSCC) is the six most common cancer globally and most common cancer in men in India. The metabolic regulation is highly altered and is considered as a hall mark… read more here.
Keywords: glycolysis apoptosis; tp53 induced; apoptosis regulator; induced glycolysis ... See more keywords
Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates
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DOI: 10.1038/nm.4290
Abstract: Nonalcoholic steatohepatitis (NASH) is a progressive disease that is often accompanied by metabolic syndrome and poses a high risk of severe liver damage. However, no effective pharmacological treatment is currently available for NASH. Here we… read more here.
Keywords: apoptosis regulator; nonalcoholic steatohepatitis; casp8 fadd; like apoptosis ... See more keywords