Twist1 sustains the apoptosis resistance in eosinophils in nasal mucosa of allergic rhinitis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108828
Abstract: Eosinophils (Eos) are the canonical effector cells in allergic rhinitis (AR) and many inflammatory diseases. The mechanism of eosinophilia occurring in the lesion sites is not fully understood yet. Twist1 protein (Twist, in short) is… read more here.
Keywords: apoptosis resistance; ras activation; activation; eos ... See more keywords
Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells
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DOI: 10.1038/onc.2016.310
Abstract: Resistance to apoptosis, for example due to overexpression of Inhibitor of Apoptosis (IAP) proteins, is associated with poor prognosis in acute myeloid leukemia (AML). Here, we identify that Smac mimetics such as BV6, which antagonizes… read more here.
Keywords: apoptosis resistance; myeloid leukemia; necroptosis; aml cells ... See more keywords
JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia
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DOI: 10.1038/s41375-022-01558-5
Abstract: Resistance to mitochondrial apoptosis predicts inferior treatment outcomes in patients with diverse tumor types, including T-cell acute lymphoblastic leukemia (T-ALL). However, the genetic basis for variability in this mitochondrial apoptotic phenotype is poorly understood, preventing… read more here.
Keywords: leukemia; mitochondrial apoptosis; jak3; apoptosis resistance ... See more keywords
M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes
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DOI: 10.1038/s41598-017-11303-z
Abstract: Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults. Nevertheless, the underlying mechanisms… read more here.
Keywords: like macrophages; fibrotic liver; macrophages fibrotic; apoptosis resistance ... See more keywords
Mutant BRAF upregulates MCL-1 to confer apoptosis resistance that is reversed by MCL-1 antagonism and cobimetinib in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.603
Abstract: 603Background: Oncogenic BRAFV600E mutations activate MAP kinase signaling and are associated with treatment resistance and poor prognosis in patients with colorectal cancer (CRC). In BRAFV600E mutant CRCs, treatment failure may be related to BRAFV600E-mediated apoptosis… read more here.
Keywords: apoptosis resistance; apoptosis; colorectal cancer; brafv600e ... See more keywords