Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway
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DOI: 10.1002/jcp.26588
Abstract: Skin squamous cell carcinoma (SCC) is generally considered as nonaggressive lesions and mainly caused by ultraviolet (UV) radiation. Gadd45a is a key component protecting skin against UV‐induced tumors. For that, the study aims to investigate… read more here.
Keywords: apoptosis senescence; apoptosis; proliferation; p53 ... See more keywords
lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells
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DOI: 10.1002/jcp.29129
Abstract: Intervertebral disc degeneration (IDD) is a complex and chronic disease that involves disc cell senescence, death, and extracellular matrix (ECM) degradation. HOTAIR, a long non‐coding RNA (lncRNA) is reportedly associated with autophagy, whereas autophagy is… read more here.
Keywords: apoptosis senescence; hotair; senescence; pulposus cells ... See more keywords
Extrinsic apoptosis and senescence involved in growth kinetics of seminoma to cisplatin
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DOI: 10.1111/1440-1681.13730
Abstract: Seminoma is the most common type of testicular germ cell tumour and is highly sensitive to cisplatin therapy, which has not been fully elucidated. In this study, we comprehensively monitored dynamic changes of TCam‐2 cells… read more here.
Keywords: tcam cells; senescence involved; apoptosis senescence; senescence ... See more keywords
The Sirt1/P53 Axis in Diabetic Intervertebral Disc Degeneration Pathogenesis and Therapeutics
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DOI: 10.1155/2019/7959573
Abstract: Intervertebral disc degeneration (IDD) is one of the major causes of low back pain. Diabetes is a risk factor for IDD and may aggravate IDD in rats; however, the mechanism is poorly understood. Previously, we… read more here.
Keywords: apoptosis senescence; p53 axis; intervertebral disc; p53 ... See more keywords
FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells
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DOI: 10.1155/2021/3843145
Abstract: Previous studies have established the pathogenic role of advanced glycation end products (AGEs) accumulation in intervertebral disc degeneration (IDD). Emerging evidence indicates that ER-phagy serves as a crucial cellular adaptive mechanism during stress conditions. This… read more here.
Keywords: fam134b mediated; treatment; mediated phagy; apoptosis senescence ... See more keywords
Corrigendum: Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
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DOI: 10.3389/fcell.2022.876000
Abstract: [This corrects the article DOI: 10.3389/fcell.2020.00836.]. read more here.
Keywords: apoptosis senescence; promote melanoma; corrigendum baicalein; baicalin promote ... See more keywords
Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism
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DOI: 10.3390/ijms22083965
Abstract: The intervertebral disc is the largest avascular organ. Autophagy is an important cell survival mechanism by self-digestion and recycling damaged components under stress, primarily nutrient deprivation. Resident cells would utilize autophagy to cope with the… read more here.
Keywords: disc cellular; apoptosis senescence; human disc; autophagy ... See more keywords
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
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DOI: 10.7554/elife.54935
Abstract: Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and aging. Apoptosis and senescence are the two major outcomes upon irreversible cellular damage. Here, we show a transition of these… read more here.
Keywords: senescence; upon telomere; apoptosis senescence; telomere shortening ... See more keywords