ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9505-0
Abstract: Apoptosis and autophagy are distinct cellular processes that can be highly interconnected. The cross talk between the two processes is indispensable in determining the overall cell fate. Although the apoptosis-promoting effect of caspases has been… read more here.
Keywords: hepatocellular carcinoma; caspase; beclin1; mitochondrial apoptosis ... See more keywords
Interleukin-1β induces pericyte apoptosis via the NF-κB pathway in diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.108
Abstract: Pericytes play a crucial role in preventing endothelial permeability by maintaining the integrity of tight junctions in endothelial cells; however, early pathological change in diabetic retinopathyis pericyte loss, which can lead to visual impairment by… read more here.
Keywords: diabetic retinopathy; permeability; endothelial cells; pericyte apoptosis ... See more keywords
FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2018.05.012
Abstract: AIMS Diabetic macroangiopathy is the main cause of morbidity and mortality in patients with diabetes. Endothelial cell injury is a pathological precondition for diabetic macroangiopathy. Fibroblast growth factor 21 (FGF21) is a key metabolic regulator… read more here.
Keywords: akt; apoptosis; pi3k akt; human umbilical ... See more keywords
Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116554
Abstract: AIMS Several adipokines have been proven to improve the therapeutic efficacy of mesenchymal stromal cells (MSCs) when used to treat ischemic heart disease. Asprosin (ASP) is a newly-discovered adipokine. ASP might also predict the severity… read more here.
Keywords: asp; erk1 sod2; mscs; apoptosis via ... See more keywords
Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.02.047
Abstract: Highlights • The administration of nanoherbal andaliman reduced apoptosis via cytochrome c and FasL.• EVOO reduces apoptosis via cytochrome c and FasL better than andaliman.• Combination Nano herbal andaliman and EVOO reduce reduced apoptosis via… read more here.
Keywords: via cytochrome; andaliman; nano herbal; apoptosis via ... See more keywords
Tanshinones induce tumor cell apoptosis via directly targeting FHIT
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DOI: 10.1038/s41598-021-91708-z
Abstract: The liposoluble tanshinones are bioactive components in Salvia miltiorrhiza and are widely investigated as anti-cancer agents, while the molecular mechanism is to be clarified. In the present study, we identified that the human fragile histidine… read more here.
Keywords: via directly; cell apoptosis; tanshinones induce; tumor cell ... See more keywords
Cyclophilin A Protects Cardiomyocytes against Hypoxia/Reoxygenation-Induced Apoptosis via the AKT/Nox2 Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/2717986
Abstract: Hypoxia/reoxygenation (H/R) accelerates the process of cardiomyocyte apoptosis during ischemia-reperfusion. Excessive reactive oxygen species (ROS) are a critical driver of oxidative stress injury. Cyclophilin A (CyPA) is a major ROS-induced factor in atherosclerosis. There is… read more here.
Keywords: hypoxia reoxygenation; apoptosis; induced apoptosis; via akt ... See more keywords
Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma
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DOI: 10.1186/s12935-021-02105-5
Abstract: Background Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of this study is to examine… read more here.
Keywords: protopine; pi3k akt; liver carcinoma; via intrinsic ... See more keywords
PPARγ/SOD2 Protects Against Mitochondrial ROS-Dependent Apoptosis via Inhibiting ATG4D-Mediated Mitophagy to Promote Pancreatic Cancer Proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.745554
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognosis. Our previous study found that peroxisome proliferator activated receptor gamma (PPARγ) was capable of enhancing glycolysis in PDAC cells. However, whether PPARγ could… read more here.
Keywords: apoptosis via; mitochondrial ros; ppar; atg4d mediated ... See more keywords
Corrigendum: Quercetin Induces Apoptosis Via Downregulation of VEGF/Akt Signaling Pathway in Acute Myeloid Leukemia Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.640750
Abstract: [This corrects the article DOI: 10.3389/fphar.2020.534171.]. read more here.
Keywords: via downregulation; downregulation vegf; quercetin induces; corrigendum quercetin ... See more keywords
C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21041298
Abstract: Apoptosis pathways in cells are classified into two pathways: the extrinsic pathway, mediated by binding of the ligand to a death receptor and the intrinsic pathway, mediated by mitochondria. Apoptosis is regulated by various proteins… read more here.
Keywords: caspase; apoptosis; via extrinsic; cancer cells ... See more keywords