Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation
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DOI: 10.1080/14756366.2017.1421181
Abstract: Abstract On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a–r, 9a–f and 11a–c) were synthesised and evaluated for… read more here.
Keywords: indolin ones; apoptotic anti; indolylmethylene hydrazono; novel indolylmethylene ... See more keywords
Pro-apoptotic, anti-metastatic, and anti-telomerase activity of Tinospora cordifolia and its active polysaccharide arabinogalactan during Benzo(a)pyrene-induced lung carcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_962_20
Abstract: BACKGROUND: The present study aims to unravel the pro-apoptotic, anti-metastatic, and anti-telomerase activity of aqueous extract of Tinospora cordifolia stem (Aq.Tc) and its active component arabinogalactan (AG) during Benzo(a)pyrene [B(a)P]-induced lung tumorigenesis in mice. MATERIALS… read more here.
Keywords: telomerase; telomerase activity; pro apoptotic; apoptotic anti ... See more keywords