Hollongdione arylidene derivatives induce antiproliferative activity against melanoma and breast cancer through pro-apoptotic and antiangiogenic mechanisms.
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DOI: 10.1016/j.bioorg.2021.105535
Abstract: The use of natural compounds as starting point for semisynthetic derivatives has already been proven as a valuable source of active anticancer agents. Hollongdione (4,4,8,14-tetramethyl-18-norpregnan-3,20-dion), obtained by few steps from dammarane type triterpenoid dipterocarpol, was… read more here.
Keywords: cancer; apoptotic antiangiogenic; antiproliferative activity; activity ... See more keywords