Multifunctional Apoptotic Bodies Engineered by Magnesium Oxide Nanoparticles for Synergistic Ischemic Skin Flap Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202503425
Abstract: Engineered extracellular vesicles (EVs) loaded with therapeutic cargos offer promise for therapeutic applications in various diseases. Yet, engineering EVs with optimal functions presents a significant challenge that necessitates the precise selection of functionally specialized vesicles… read more here.
Keywords: flap; apoptotic bodies; magnesium oxide; mgo abs ... See more keywords
Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba2987
Abstract: Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation. Engineered extracellular vesicles (EVs) carrying therapeutic molecules are promising candidates for disease therapies. Yet, engineering EVs with optimal functions is a challenge that requires… read more here.
Keywords: chimeric apoptotic; inflammation; apoptotic bodies; membrane ... See more keywords
Evaluating the pro-survival potential of apoptotic bodies derived from 2D- and 3D- cultured adipose stem cells in ischaemic flaps
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-024-02533-1
Abstract: In the realm of large-area trauma flap transplantation, averting ischaemic necrosis emerges as a pivotal concern. Several key mechanisms, including the promotion of angiogenesis, the inhibition of oxidative stress, the suppression of cell death, and… read more here.
Keywords: flap survival; evaluating pro; apoptotic bodies; stem cells ... See more keywords
Tailored brain metastatic tumor cells-derived apoptotic bodies ameliorate Alzheimer’s disease by promoting microglia efferocytosis and neuroinflammation mitigation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-025-03750-y
Abstract: Neuroinflammation, characterized by microglial overactivation and oxidative stress, plays a critical role in the initiation and progression of Alzheimer’s disease (AD). In this study, we focus on simulating the natural efferocytosis process to reprogram microglial… read more here.
Keywords: alzheimer disease; brain; neuroinflammation; apoptotic bodies ... See more keywords
A pregnancy hormone-cell death link promotes enhanced lupus-specific immunological effects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1051779
Abstract: Women of reproductive age demonstrate an increased incidence of systemic lupus erythematosus, and reproductive hormones have been implicated in disease progression. Additionally, pregnancy can be associated with disease “flares”, the reasons for which remain obscure.… read more here.
Keywords: lupus associated; cell; induced apoptotic; pregnancy hormone ... See more keywords
Exploring the Metabolic Differences between Cisplatin- and UV Light-Induced Apoptotic Bodies in HK-2 Cells by an Untargeted Metabolomics Approach
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087237
Abstract: Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal… read more here.
Keywords: metabolic differences; apoptosis; differences cisplatin; cisplatin light ... See more keywords