Optogenetic Control of Non‐Apoptotic Cell Death
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100424
Abstract: Abstract Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP tools allow reconstruction of the key molecular steps involved in… read more here.
Keywords: non apoptotic; apoptotic cell; cell death; optogenetic control ... See more keywords
Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205913
Abstract: Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and autophagy. However, the significance of… read more here.
Keywords: cell death; non apoptotic; apoptotic cell; entosis ... See more keywords
Autophagic and apoptotic cell death induced by the quinoline derivative 2‐(6‐methoxynaphthalen‐2‐yl)quinolin‐4‐amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21916
Abstract: Pancreatic cancer (PC) is among the most lethal cancers and is resistant to existing therapies, which highlights the need for new and alternative therapeutic treatments. Autophagy is emerging as one of the alternative cell death… read more here.
Keywords: cell death; cell; pancreatic cancer; apoptotic cell ... See more keywords
Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847801
Abstract: Efferocytosis is essential for homeostasis and prevention of the inflammatory and autoimmune diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein previously implicated in efferocytosis, with mutations in CD93 predisposing patients to efferocytosis‐associated… read more here.
Keywords: soluble cd93; apoptotic cells; apoptotic cell; cd93 ... See more keywords
Single‐cell biology uncovers apoptotic cell death and its spatial organization as a potential modifier of tumor diversity in HCC
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32345
Abstract: HCC is a highly aggressive and heterogeneous cancer type with limited treatment options. Identifying drivers of tumor heterogeneity may lead to better therapeutic options and favorable patient outcomes. We investigated whether apoptotic cell death and… read more here.
Keywords: cell death; cell; death spatial; apoptotic cell ... See more keywords
Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22488
Abstract: Insulinomas originate from pancreatic β cells and it is the most widely known tumor. Indomethacin is a nonsteroidal anti‐inflammatory drug, which is used for blocking the production of some natural substances that cause inflammation and… read more here.
Keywords: secretion; insulin secretion; apoptotic cell; indomethacin ... See more keywords
In Vitro Apoptotic Cell Death Assessment.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1091-6_17
Abstract: Chemical compounds induce cytotoxicity by various mechanisms, including interference in membrane integrity, metabolism, cellular component degradation or release, and cell division. Between the classic death pathways, namely, autophagy, apoptosis, and necrosis, apoptosis have been in… read more here.
Keywords: death; death assessment; apoptotic cell; vitro apoptotic ... See more keywords
A BioDesign Approach to Obtain High Yields of Biosimilars by Anti-apoptotic Cell Engineering: a Case Study to Increase the Production Yield of Anti-TNF Alpha Producing Recombinant CHO Cells
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-017-2540-2
Abstract: Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three areas, particularly cancer, immunological disorders,… read more here.
Keywords: production; anti apoptotic; cho cells; apoptotic cell ... See more keywords
Attenuation of apoptotic cell detection triggers thymic regeneration after damage.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109789
Abstract: The thymus, which is the primary site of T cell development, is particularly sensitive to insult but also has a remarkable capacity for repair. However, the mechanisms orchestrating regeneration are poorly understood, and delayed repair is… read more here.
Keywords: regeneration; apoptotic cell; thymic regeneration; damage ... See more keywords
ER stress related lipid accumulation and apoptotic cell death in nonalcoholic fatty liver diesease
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.204
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that ranges from benign steatosis to nonalcoholic steatohepatitis (NASH) . The role of cholesterol alterations in NAFLD progression have been shown in various… read more here.
Keywords: nonalcoholic fatty; stress; apoptotic cell; cell death ... See more keywords
Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.02.017
Abstract: Physapubescin B, a steroidal compound extracted from the plant Physalis pubescens L. (Solanaceae), has been reported to possess anti-cancer potential, whereas the molecular mechanism remains elusive. In this study, we first demonstrated that physapubescin B… read more here.
Keywords: ros mediated; physapubescin; apoptotic cell; cell death ... See more keywords