Quantifying Microglial Phagocytosis of Apoptotic Cells in the Brain in Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Protocols in Immunology"
DOI: 10.1002/cpim.49
Abstract: Apoptosis is a ubiquitous process occurring in the brain under both physiological and pathological conditions. The central nervous system (CNS) requires an active and efficient clean‐up system to prevent the spillover of intracellular contents into… read more here.
Keywords: phagocytosis apoptotic; phagocytosis; apoptotic cells; microglial phagocytosis ... See more keywords
Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847801
Abstract: Efferocytosis is essential for homeostasis and prevention of the inflammatory and autoimmune diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein previously implicated in efferocytosis, with mutations in CD93 predisposing patients to efferocytosis‐associated… read more here.
Keywords: soluble cd93; apoptotic cells; apoptotic cell; cd93 ... See more keywords
Bioluminescence Resonance Energy Transfer (BRET) Coupled Near-Infrared Imaging of Apoptotic Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9940-8_2
Abstract: Detection of apoptotic cells is crucial for understanding the mechanism of diseases and for therapy development. So far, visible-emitting fluorescent probes such as FITC-labeled Annexin V has been widely used for the detection of apoptotic… read more here.
Keywords: energy transfer; apoptotic cells; near infrared; resonance energy ... See more keywords
Tissue‐Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.10.006
Abstract: SUMMARY Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll‐like receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms. Here we identified macrophage populations that continually engulf ACs… read more here.
Keywords: silent clearance; nucleic acids; apoptotic cells; expression ... See more keywords
The B cell response to both protein and nucleic acid antigens displayed on apoptotic cells are dependent on endosomal pattern recognition receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2020.102582
Abstract: In systemic autoimmune diseases such as systemic lupus erythematosus (SLE), B cell tolerance is lost and there is a production of autoantibodies that drive pathology. The specificities of these antibodies are towards a wide range… read more here.
Keywords: pattern recognition; endosomal pattern; recognition receptors; apoptotic cells ... See more keywords
Apoptotic cells enhance pathogenesis of Listeria monocytogenes.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.02.036
Abstract: Infections by pathogenic microorganisms elicit host immune responses, which crucially limit those infections. Pathogens employ various strategies to evade host immunity. We have identified the exploitation of the repertoire of potent immunosuppressive responses elicited normally… read more here.
Keywords: cells enhance; enhance pathogenesis; apoptotic cells; pathogenesis ... See more keywords
Artificial apoptotic cells/VEGF-loaded injectable hydrogel united with immunomodification and revascularization functions to reduce cardiac remodeling after myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "Nano Today"
DOI: 10.1016/j.nantod.2021.101227
Abstract: Abstract Currently, single therapeutic strategy designed for only boosting anti-inflammatory response or angiogenesis in treating myocardial infarction (MI) has met with limited success due to complicated pathological mechanism. Herein, we propose to create artificial apoptotic… read more here.
Keywords: injectable hydrogel; vegf; apoptotic cells; myocardial infarction ... See more keywords
Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43535-6
Abstract: Variants of triggering receptor expressed on myeloid cells 2 (TREM2) are associated with an increased incidence of Alzheimer’s disease, as well as other neurodegenerative disorders. Using a newly developed, highly sensitive reporter cell model, consisting… read more here.
Keywords: transducing trem2; apoptotic cells; ligands apoptotic; aminophospholipids signal ... See more keywords
A novel crosstalk between autophagosomes and phagosomes that facilitates the clearance of apoptotic cells
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2080384
Abstract: ABSTRACT During an animal’s life, many cells undergo apoptosis, a form of genetically programmed cell death. These cells are swiftly engulfed by other cells through phagocytosis and subsequently degraded inside phagosomes. Phagocytosis and macroautophagy/autophagy are… read more here.
Keywords: clearance; cell; autophagosomes phagosomes; novel crosstalk ... See more keywords
Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15087
Abstract: Recipient infusion of donor apoptotic cells is an emerging strategy for inducing robust transplantation tolerance. Daily clearance of billions of self‐apoptotic cells relies on homeostatic engagement of phagocytic receptors, in particular, receptors of the tyrosine… read more here.
Keywords: tolerance; apoptotic cells; mertk; receptor ... See more keywords
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aai8132
Abstract: Local macrophage clean-up Infection, especially by helminths or bacteria, can cause tissue damage (see the Perspective by Bouchery and Harris). Minutti et al. studied mouse models of helminth infection and fibrosis. They expressed surfactant protein… read more here.
Keywords: tissue repair; apoptotic cells; infection; tissue ... See more keywords