Synthesis, Antitumor of Sinomenine Derivatives and Apoptotic Induction via IL-6/PI3K/Akt/NF-κB Signaling Pathway in MCF-7 Cells.
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DOI: 10.1002/cmdc.202200234
Abstract: Natural products have been widely considered as an important resource for new drugs or lead compounds. Sinomenine (SIN) and its derivatives exert antitumor activity via regulation of inflammatory mediators. For these reasons we synthesized three… read more here.
Keywords: pi3k akt; apoptotic induction; antitumor; antitumor activity ... See more keywords
Evaluation of antiproliferative activity, apoptotic induction and LC-HRMS/MS analyses of the VLC fractions of L. numidicum
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DOI: 10.1080/14786419.2022.2084738
Abstract: Abstract In this study, six vacuum liquid chromatography (VLC) fractions (F1–F6) of the n-BuOH extract of L. numidicum Murb. (BELN) were examined for their anticancer capacity. The composition of secondary metabolites was analyzed by LC-HRMS/MS.… read more here.
Keywords: evaluation antiproliferative; apoptotic induction; vlc fractions; activity ... See more keywords
PO-365 Isothiocyanates as potent epigenetic regulators in human malignant melanoma chemoprevention
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DOI: 10.1136/esmoopen-2018-eacr25.393
Abstract: Introduction Glucosinolates (GLs) are phytochemicals abundant in cruciferous vegetables, which are hydrolysed, by myrosinase, to a range of isothiocyanates (ITCs). These molecules are biologically active metabolites capable of mediating a plurality of anticancer effects including… read more here.
Keywords: melanoma; 365 isothiocyanates; human malignant; apoptotic induction ... See more keywords