Targeting a novel apoptotic pathway in human disease
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202200231
Abstract: Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including… read more here.
Keywords: targeting novel; apoptotic pathway; disease; death ... See more keywords
Cell death induction (extrinsic versus intrinsic apoptotic pathway) by intestinal ischemia–reperfusion injury in rats is time-depended
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Surgery International"
DOI: 10.1007/s00383-020-04817-7
Abstract: We investigate the mechanism of intestinal cell apoptosis and its relation to the time of reperfusion in a rat model of intestinal ischemia–reperfusion (IR). Rats were divided into 4 groups: Sham-24 and Sham-48 rats underwent… read more here.
Keywords: time; reperfusion; cell apoptosis; apoptotic pathway ... See more keywords
Ganoderma atrum polysaccharide improves doxorubicin-induced cardiotoxicity in mice by regulation of apoptotic pathway in mitochondria.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.08.144
Abstract: The present study aimed to determine the cardioprotective effect of Ganoderma atrum polysaccharide (PSG-1) in doxorubicin (DOX)-treated mice and its underlying mechanism. Results indicated that PSG-1 treatment significantly alleviated DOX-induced myocardial damage via attenuating apoptosis… read more here.
Keywords: induced cardiotoxicity; psg; ganoderma atrum; dox ... See more keywords
SpBOK inhibits WSSV infection by regulating the apoptotic pathway in mud crab (Scylla paramamosain).
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2019.103603
Abstract: B-cell lymphoma 2 (Bcl-2) related ovarian killer (BOK) is a member of the Bcl-2 family, which has a similar function to BAX and BAK in the process of apoptosis. However, how BOK activates the intrinsic… read more here.
Keywords: mud crab; mud; infection; apoptotic pathway ... See more keywords
Capsella bursa-pastoris (L.) Medic. extract alleviate cataract development by regulating the mitochondrial apoptotic pathway of the lens epithelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114783
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Capsella bursa-pastoris (L.) Medic. (CBP) is a cruciferous plant valuable in reducing fever, improving eyesight and calming the liver. This herb was recorded in the Compendium of Materia Medica for cataract treatment. AIM… read more here.
Keywords: epithelial cells; lens epithelial; mitochondrial apoptotic; cataract ... See more keywords
Perturbations in the apoptotic pathway and mitochondrial network dynamics in peripheral blood mononuclear cells from bipolar disorder patients
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2017.83
Abstract: Bipolar disorder (BD) is a severe psychiatric disorder characterized by phasic changes of mood and can be associated with progressive structural brain change and cognitive decline. The numbers and sizes of glia and neurons are… read more here.
Keywords: blood mononuclear; mononuclear cells; disorder; peripheral blood ... See more keywords
β-Elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20190804
Abstract: Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is considered the most common aggressive subtype of lymphoma. A number of DLBCL patients fail to achieve a response to currently available therapies or develop resistance. β-Elemene is… read more here.
Keywords: dlbcl; hulc; diffuse large; lymphoma ... See more keywords
Evolutionary novelty in the apoptotic pathway of aphids
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2013847117
Abstract: Significance Apoptotic processes play an important role in the development and physiology of almost all metazoan clades. In the highly diverse group of insects, apoptotic pathways have been characterized in only a few dipteran and… read more here.
Keywords: insects; novelty apoptotic; pathway aphids; evolutionary novelty ... See more keywords
Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00758
Abstract: Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis… read more here.
Keywords: traditional chinese; target; pharmacology; chinese medicines ... See more keywords
Neuroregeneration of injured peripheral nerve by fraction B of catfish epidermal secretions through the reversal of the apoptotic pathway and DNA damage
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1085314
Abstract: Introduction: Crush injuries occur from acute traumatic nerve compression resulting in different degrees of neural damage leading to permanent functional deficits. Recently, we have shown that administration of Fraction B (FB) derived from catfish epidermal… read more here.
Keywords: dna; damage; apoptotic pathway; crush ... See more keywords
Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020194
Abstract: Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular… read more here.
Keywords: cell; apoptotic pathway; plant based; pathway ... See more keywords