Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature cell biology"
DOI: 10.1038/s41556-018-0054-y
Abstract: Ageing of haematopoietic stem cells (HSCs) contributes to deficits in the aged haematopoietic system. HSC decline is driven in part by DNA damage accumulation; yet, how ageing impacts the acute DNA damage response (DDR) of… read more here.
Keywords: dna damage; apoptotic priming; response; damage ... See more keywords
Abstract 6130: Cancer sensitivity to therapy is constrained by apoptosis regulation in cells of origin
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6130
Abstract: Many chemotherapeutic agents target cellular components or processes that are present in all cancers, yet clinical responses to these agents vary greatly between cancer types and even patient age - the basis for these broad-scale… read more here.
Keywords: apoptosis; sensitivity; therapy; regulation ... See more keywords
Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition.
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DOI: 10.1158/2159-8290.cd-19-1469
Abstract: The cell of origin of oncogenic transformation is a determinant of therapeutic sensitivity, but the mechanisms governing cell-of-origin-driven differences in therapeutic response have not been delineated. Leukemias initiating in hematopoietic stem cells (HSC) are less… read more here.
Keywords: sensitivity; apoptotic priming; cell origin; lsd1 inhibition ... See more keywords