The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells† †Electronic supplementary information (ESI) available: Experimental section Fig. S1–S4 and Tables S1–S4. See DOI: 10.1039/c8sc03390k
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DOI: 10.1039/c8sc03390k
Abstract: We reveal a novel interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells, and propose that this interaction is required for apoptosis activation in cancer cells.… read more here.
Keywords: apoptotic proteins; anti apoptotic; apoptosis; proteins naf ... See more keywords
The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes
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DOI: 10.7554/elife.88329
Abstract: Anti-apoptotic proteins such as BCL-XL promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins, termed BH3-mimetics, is revolutionizing how… read more here.
Keywords: puma; bh3 mimetic; carboxyl terminal; anti apoptotic ... See more keywords