APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
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DOI: 10.1038/s41380-022-01454-5
Abstract: Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer’s disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with CRISPR-Cas9 gene editing to investigate the contribution of chromosome 21… read more here.
Keywords: app dyrk1a; t21; pathology; synaptic vesicle ... See more keywords