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   Articles with "app knock" as a keyword



The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives

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recommendations! Published in 2023 at "Brain and Behavior"

DOI: 10.1002/brb3.2953

Abstract: The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as… read more here.

Keywords: knock mice; senile plaque; plaque morphological; morphological differences ... See more keywords

Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-89051-8

Abstract: APP knock-in (KI) mice serve as an exciting new model system to understand amyloid beta (Aβ) pathology, overcoming many of the limitations of previous overexpression-based model systems. The APPSAA mouse model (containing the humanized APP… read more here.

Keywords: characterization reveals; app knock; longitudinal characterization; pathology ... See more keywords

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abm6155

Abstract: We previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (AppNL-G-F and AppNL-F mice). We have now generated App knock-in… read more here.

Keywords: knock; mice; knock mouse; app knock ... See more keywords

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

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recommendations! Published in 2022 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2022.878303

Abstract: Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein homeostasis including… read more here.

Keywords: pathology; appnl mice; app knock; mice ... See more keywords