The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2953
Abstract: The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as… read more here.
Keywords: knock mice; senile plaque; plaque morphological; morphological differences ... See more keywords
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm6155
Abstract: We previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (AppNL-G-F and AppNL-F mice). We have now generated App knock-in… read more here.
Keywords: knock; mice; knock mouse; app knock ... See more keywords
Autophagy Impairment in App Knock-in Alzheimer’s Model Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.878303
Abstract: Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein homeostasis including… read more here.
Keywords: pathology; appnl mice; app knock; mice ... See more keywords