HIF-1α is a “brake” in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells
Sign Up to like & getrecommendations! Published in 2024 at "Mycotoxin Research"
DOI: 10.1007/s12550-024-00525-6
Abstract: Mycotoxins have been shown to activate multiple mechanisms that may potentially lead to the progression of Alzheimer’s disease (AD). Overexpression/aberrant cleavage of amyloid precursor protein (APP) and hyperphosphorylation of tau (P-tau) is hallmark pathologies of… read more here.
Keywords: jnk; bv2 cells; tau; app tau ... See more keywords
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
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DOI: 10.1038/s41420-021-00435-x
Abstract: Alzheimer’s disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins. Evidence has… read more here.
Keywords: bmp4 overexpression; alzheimer disease; bmp4; disease ... See more keywords
Peptide Interference with APP and Tau Association: Relevance to Alzheimer’s Disease Amelioration
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DOI: 10.3390/ijms21093270
Abstract: The two major proteins involved in Alzheimer’s disease (AD) are the amyloid precursor protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other. Four possible peptides APP1 (390–412), APP2… read more here.
Keywords: peptide interference; alzheimer disease; disease; app tau ... See more keywords