ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
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DOI: 10.1016/j.cell.2016.12.044
Abstract: Human apolipoprotein E (ApoE) apolipoprotein is primarily expressed in three isoforms (ApoE2, ApoE3, and ApoE4) that differ only by two residues. ApoE4 constitutes the most important genetic risk factor for Alzheimer's disease (AD), ApoE3 is… read more here.
Keywords: transcription; app transcription; kinase; apoe3 apoe4 ... See more keywords