Application and Study of ROCK Inhibitors in Pulmonary Fibrosis: Recent Developments and Future Perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01753
Abstract: Rho-associated coiled-coil-containing kinases (ROCKs), serine/threonine protein kinases, were initially identified as downstream targets of the small GTP-binding protein Rho. Pulmonary fibrosis (PF) is a lethal disease with limited therapeutic options and a particularly poor prognosis.… read more here.
Keywords: rock; study rock; pulmonary fibrosis; application study ... See more keywords
Application study of infrared free-electron lasers towards the development of amyloidosis therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Synchrotron Radiation"
DOI: 10.1107/s1600577522007330
Abstract: An infrared free-electron laser was applied to dissociate amyloid fibrils of a peptide as a goal of the development of a novel therapeutic strategy for amyloidosis. Solid evidence for β-sheet to α-helix conversion in the… read more here.
Keywords: free electron; development; application study; amyloidosis ... See more keywords