Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00028.2018
Abstract: Over the last decade, genome-wide association studies (GWAS) have propelled the discovery of thousands of loci associated with complex diseases. The focus is now turning toward the function of these association signals, determining the causal… read more here.
Keywords: functionality; genome editing; applications genome; gwas ... See more keywords
Current status and applications of genome-scale metabolic models
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology"
DOI: 10.1186/s13059-019-1730-3
Abstract: Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction associations for entire metabolic genes in an organism, and can be simulated to predict metabolic fluxes for various systems-level metabolic studies. Since the first GEM for Haemophilus influenzae… read more here.
Keywords: genome scale; current status; metabolic models; applications genome ... See more keywords