Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.017
Abstract: &NA; Amyloid‐&bgr; (A&bgr;) peptides occur in the brains of patients with Alzheimer's disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP… read more here.
Keywords: appnl mice; subtle behavioral; increased prefrontal; mice ... See more keywords
Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2020.117707
Abstract: BACKGROUND In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known phenomenon. Recently, we described a high incidence of inter-individual regional heterogeneity in terms of asymmetry of… read more here.
Keywords: appnl mice; performance; spatial learning; microglial activation ... See more keywords
Reduced Autophagy in Aged Trigeminal Neurons Causes Amyloid β Diffusion.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of dental research"
DOI: 10.1177/00220345231156095
Abstract: The relationship between oral health and the development of Alzheimer's disease (AD) in the elderly is not yet well understood. In this regard, the association between aging or neurodegeneration of the trigeminal nervous system and… read more here.
Keywords: diffusion; appnl mice; autophagy aged; vmes neurons ... See more keywords
Autophagy Impairment in App Knock-in Alzheimer’s Model Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.878303
Abstract: Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein homeostasis including… read more here.
Keywords: pathology; appnl mice; app knock; mice ... See more keywords