Radical Approach to the Chiral Quaternary Center in Asperaculin A: Synthesis of 9-Deoxyasperaculin A.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03854
Abstract: Diastereoselective approaches toward the synthesis of a marine-derived sesquiterpenoid fungal metabolite, asperaculin A, are delineated, combining step economy and simplicity. Two distinct lactonization sequences from a common intermediate led to the first synthesis of 9-deoxyasperaculin… read more here.
Keywords: asperaculin; approach chiral; synthesis deoxyasperaculin; radical approach ... See more keywords
A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12404
Abstract: Enantioenriched tertiary alkyl halides are prevalent in bioactive molecules and can serve as versatile synthetic intermediates to construct complex structures. While conventional access to these motifs often hinges on stereoselective carbon-halogen or carbon-carbon bond formation… read more here.
Keywords: approach chiral; desymmetric approach; tertiary alkyl; unified desymmetric ... See more keywords
Convenient approach to chiral 4-monosubstituted 1,3-oxazolidine-2-thiones
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic Communications"
DOI: 10.1080/00397911.2017.1368083
Abstract: ABSTRACT Chiral 4-monosubstituted 1,3-oxazolidine-2-thiones are regarded as one of the modified version of Evans auxiliaries in asymmetric aldol condensation, which can generate two adjacent chiral carbon centers in one time They have advantages over Evans… read more here.
Keywords: chiral monosubstituted; oxazolidine thiones; approach chiral; convenient approach ... See more keywords