GPCRomics: An Approach to Discover GPCR Drug Targets.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2019.04.001
Abstract: G protein-coupled receptors (GPCRs) are targets for ∼35% of approved drugs but only ∼15% of the ∼800 human GPCRs are currently such targets. GPCRomics, the use of unbiased, hypothesis-generating methods [e.g., RNA-sequencing (RNA-seq)], with tissues… read more here.
Keywords: drug targets; targets gpcromics; gpcr drug; discover gpcr ... See more keywords
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00678
Abstract: NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation,… read more here.
Keywords: discover potent; inducing kinase; scaffold hopping; hopping approach ... See more keywords