Identifying the landscape of developmental toxicity new approach methodologies
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2075
Abstract: The dynamics and complexities of in utero fetal development create significant challenges in transitioning from lab animal‐centric developmental toxicity testing methods to assessment strategies based on new approach methodologies (NAMs). Nevertheless, considerable progress is being… read more here.
Keywords: developmental toxicity; new approach; landscape developmental; toxicity ... See more keywords
Community‐Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environmental Contaminants
Sign Up to like & getrecommendations! Published in 2024 at "Birth Defects Research"
DOI: 10.1002/bdr2.2395
Abstract: The paper analyzes opportunities for integrating Open access resources (Abstract Sifter, US EPA and NTP Toxicity Value and Toxicity Reference [ToxVal/ToxRefDB]) and New Approach Methodologies (NAM) integration into Community Engaged Research (CEnR). read more here.
Keywords: methodologies nam; open access; new approach; approach methodologies ... See more keywords
New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5584
Abstract: Multiple in vivo test guidelines focusing on the estrogen, androgen, thyroid, and steroidogenesis pathways have been developed and validated for mammals, amphibians, or fish. However, these tests are resource‐intensive and often use a large number… read more here.
Keywords: toxicology; endocrine activity; new approach; chemistry ... See more keywords
The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200231
Abstract: The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment,… read more here.
Keywords: european commission; new approach; sustainability; strategy ... See more keywords
Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Toxicology"
DOI: 10.1007/s00204-024-03945-6
Abstract: Chlorpyrifos (CPF) is an organophosphorus pesticide of concern because many in vivo animal studies have demonstrated developmental toxicity exerted by this substance; however, despite its widespread use, evidence from epidemiological studies is still limited. In… read more here.
Keywords: new approach; approach methodologies; toxicity; developmental toxicity ... See more keywords
From Pipeline to Plant Protection Products: Using New Approach Methodologies (NAMs) in Agrochemical Safety Assessment.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c00958
Abstract: The human population will be approximately 9.7 billion by 2050, and food security has been identified as one of the key issues facing the global population. Agrochemicals are an important tool available to farmers that… read more here.
Keywords: early stage; new approach; approach methodologies; methodologies nams ... See more keywords
Leveraging new approach methodologies: ecotoxicological modelling of endocrine disrupting chemicals to Danio rerio through machine learning and toxicity studies
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2024.2400324
Abstract: Abstract New approach methodologies (NAMs) offer information tailored to the intended application while reducing the use of animals. NAMs aim to develop quantitative structure-activity relationship (QSAR) and quantitive-Read-Across structure-activity relationship (q-RASAR) models to predict and… read more here.
Keywords: new approach; approach methodologies; toxicity; endocrine disrupting ... See more keywords
New approach methodologies (NAMs): identifying and overcoming hurdles to accelerated adoption
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology Research"
DOI: 10.1093/toxres/tfae044
Abstract: Abstract New approach methodologies (NAMs) can deliver improved chemical safety assessment through the provision of more protective and/or relevant models that have a reduced reliance on animals. Despite the widely acknowledged benefits offered by NAMs,… read more here.
Keywords: chemical safety; nams identifying; new approach; approach methodologies ... See more keywords
RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.930148
Abstract: By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or… read more here.
Keywords: new approach; database; project; approach methodologies ... See more keywords
New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches
Sign Up to like & getrecommendations! Published in 2025 at "Toxics"
DOI: 10.3390/toxics13080693
Abstract: Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products. While single chemical entities were used to design and validate sophisticated safety… read more here.
Keywords: sensitization; use new; new approach; approach methodologies ... See more keywords