A Computational Systems Approach to Rational Design of Nose-to-Brain Delivery of Biopharmaceutics
Sign Up to like & getrecommendations! Published in 2019 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.9b04885
Abstract: In this work, a computational systems approach, comprising models at different time and length scales, is developed to elucidate the fundamental chemical, physical, transport, and biological proces... read more here.
Keywords: nose brain; approach rational; design nose; rational design ... See more keywords
Systems approach to rational combination therapy: PARP inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20191092
Abstract: Poly (ADP-ribose) polymerase inhibitors (PARPi) have demonstrated activity across a broad spectrum of molecular backgrounds and tumor types, with the greatest activity observed in patients with aberrations in the homologous recombination DNA damage repair pathway.… read more here.
Keywords: systems approach; therapy; combination; adaptive responses ... See more keywords