A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00682
Abstract: Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) family of proteins comprising… read more here.
Keywords: reveals novel; multifaceted hit; family; approach reveals ... See more keywords
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-50346-2
Abstract: Omics data facilitate the gain of novel insights into the pathophysiology of diseases and, consequently, their diagnosis, treatment, and prevention. To this end, omics data are integrated with other data types, e.g., clinical, phenotypic, and… read more here.
Keywords: integration; chronic kidney; approach reveals; integration approach ... See more keywords
Mixture-modeling approach reveals global and local processes in visual crowding.
Sign Up to like & getrecommendations! Published in 2022 at "Scientific reports"
DOI: 10.1038/s41598-022-10685-z
Abstract: Crowding refers to the inability to recognize objects in clutter, setting a fundamental limit on various perceptual tasks such as reading and facial recognition. While prevailing models suggest that crowding is a unitary phenomenon occurring… read more here.
Keywords: approach reveals; mixture modeling; crowding; configuration ... See more keywords
A Click-Chemistry Approach Reveals the BET Inhibitor Mechanism of Action.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-120
Abstract: Click chemistry-based modification of BET inhibitors allows use as molecular probes in vitro and in vivo. read more here.
Keywords: click chemistry; approach reveals; chemistry; chemistry approach ... See more keywords
Integrative approach reveals two new species of Obama (Platyhelminthes: Tricladida) from the South-Brazilian Atlantic Forest.
Sign Up to like & getrecommendations! Published in 2018 at "Zootaxa"
DOI: 10.11646/zootaxa.4455.1.4
Abstract: The genus Obama Carbayo et al., 2013 includes 38 species, being the most species-rich within Geoplaninae. Species of this genus show a similar anatomy regarding their copulatory apparatus, which may hinder species differentiation. In this… read more here.
Keywords: atlantic forest; approach reveals; two new; new species ... See more keywords
A multidisciplinary approach reveals a new species of glassfrog from Colombia (Anura: Centrolenidae: Nymphargus)
Sign Up to like & getrecommendations! Published in 2023 at "Zootaxa"
DOI: 10.11646/zootaxa.5271.1.1
Abstract: Anurans of the family Centrolenidae are a highly diverse clade of Neotropical treefrogs. In the last two decades, glassfrogs have become a model system for studies in ecology and evolutionary biology, in part because their… read more here.
Keywords: multidisciplinary approach; centrolenidae; approach reveals; reveals new ... See more keywords
Multi-Platform Sequencing Approach Reveals a Novel Transcriptome Profile in Pseudorabies Virus
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.02708
Abstract: Third-generation sequencing is an emerging technology that is capable of solving several problems that earlier approaches were not able to, including the identification of transcripts isoforms and overlapping transcripts. In this study, we used long-read… read more here.
Keywords: approach reveals; reveals novel; platform sequencing; multi platform ... See more keywords
Metabolomics Approach Reveals Important Glioblastoma Plasma Biomarkers for Tumor Biology
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108813
Abstract: Glioblastoma (GB) is the most aggressive and frequent primary malignant tumor of the central nervous system and is associated with poor overall survival even after treatment. To better understand tumor biochemical alterations and broaden the… read more here.
Keywords: plasma biomarkers; metabolomics approach; glioblastoma; approach reveals ... See more keywords
A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19030173
Abstract: Marine sponges commonly host a repertoire of bacterial-associated organisms, which significantly contribute to their health and survival by producing several anti-predatory molecules. Many of these compounds are produced by sponge-associated bacteria and represent an incredible… read more here.
Keywords: antarctic sponges; metataxonomic approach; approach reveals; bacterial communities ... See more keywords
An Integrated Analytical Approach Reveals Trichome Acylsugar Metabolite Diversity in the Wild Tomato Solanum pennellii
Sign Up to like & getrecommendations! Published in 2020 at "Metabolites"
DOI: 10.3390/metabo10100401
Abstract: Acylsugars constitute an abundant class of pest- and pathogen-protective Solanaceae family plant-specialized metabolites produced in secretory glandular trichomes. Solanum pennellii produces copious triacylated sucrose and glucose esters, and the core biosynthetic pathway producing these compounds… read more here.
Keywords: analytical approach; approach reveals; integrated analytical; reveals trichome ... See more keywords