Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.03.002
Abstract: Recent crystal structures of multiple G protein-coupled receptors (GPCRs) have revealed a highly conserved intracellular pocket that can be used to modulate these receptors from the inside. This novel intracellular site partially overlaps with the… read more here.
Keywords: intracellular receptor; approach target; novel approach; modulation novel ... See more keywords
A metabolomic approach to target antimalarial metabolites in the Artemisia annua fungal endophytes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82201-8
Abstract: Fungal endophytes are a major source of anti-infective agents and other medically relevant compounds. However, their classical blinded-chemical investigation is a challenging process due to their highly complex chemical makeup. Thus, utilizing cheminformatics tools such… read more here.
Keywords: approach target; antimalarial metabolites; artemisia annua; metabolomic approach ... See more keywords
An antisensible approach to target KRAS.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.356.6343.1134-t
Abstract: Cancer Mutations that cause activation of the KRAS oncogene are common in human cancer, including treatment-resistant tumor types such as lung and pancreatic cancer. KRAS is notoriously difficult to target with small molecules. To overcome… read more here.
Keywords: approach target; antisensible approach; target; target kras ... See more keywords