A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-17-0741
Abstract: Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as chloroquine or quinacrine have been used as lysosomal inhibitors, but fail to inhibit… read more here.
Keywords: growth; molecular target; unified approach; cancer ... See more keywords
Bispecific antibodies and its applications: a novel approach for targeting SARS-Cov-2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2022-0068
Abstract: Abstract The COVID-19 pandemic remains a severe global threat, with the world engulfed in the struggle against the disease’s second or third waves, which are approaching frightening proportions in terms of cases and mortality in… read more here.
Keywords: antibodies applications; applications novel; approach targeting; novel approach ... See more keywords
Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph18041616
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a significant clinical and epidemiological problem that affects around 25% of the adult global population. A large body of clinical evidence highlights that NAFLD is associated with increased liver-related… read more here.
Keywords: targeting gut; nafld; gut microbiota; approach targeting ... See more keywords