A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700137
Abstract: Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo‐aging. Across the solar radiation spectrum, UV light is the main cause… read more here.
Keywords: toward development; photoprotection; substituted purines; multitarget approach ... See more keywords
Aromatization-driven Grob-fragmentation approach toward polyazaacenes. Synthesis and amination of multi-functionalized diazapentacenes
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.130689
Abstract: Abstract A general approach toward the synthesis of multi-functionalized diazapentacene derivatives 1, using 1,2,3,4-tetrachloro-5,5-dimethoxycyclopentadiene (TDCp, 2), a substituted benzene-1,2-diamine (ADA, 6), and a naphthalene-1,4-dione (BQ, 3) as the building units, is described. The synthesis basically… read more here.
Keywords: aromatization driven; driven grob; approach toward; synthesis ... See more keywords
A stereotetrad-centered approach toward pironetin: Dead ends, Detour, and evolution of the synthetic strategy
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131660
Abstract: Abstract Pironetin is a unique α-tubulin inhibitor and has been of utmost interest in the synthetic community. Based on the enabling method to access various stereotriads and stereotetrads, we devised a new total synthesis of… read more here.
Keywords: stereotetrad centered; centered approach; toward pironetin; evolution ... See more keywords
Chemoproteomic Approach toward Probing the Interactomes of Perfluoroalkyl Substances.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c01948
Abstract: Poly- and perfluoroalkyl substances (PFASs) are widely used in industrial products and consumer goods. Due to their extremely recalcitrant nature and potential bioaccumulation and toxicity, exposure to PFASs may result in adverse health outcomes in… read more here.
Keywords: chemoproteomic approach; desthiobiotin; pfopa; perfluoroalkyl substances ... See more keywords
Simple Approach toward N-Heterocyclic Carbene-Protected Gold Nanoclusters.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c04200
Abstract: Little advance has been made toward developing alternative bottom-up synthetic strategies for N-heterocyclic carbene (NHC)-stabilized gold nanoclusters, although this unique class of nanomaterials has exhibited exciting properties. We report in this work a simple and… read more here.
Keywords: gold nanoclusters; approach toward; toward heterocyclic; simple approach ... See more keywords
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01457
Abstract: Lysine acetylation is an epigenetic mark that is principally recognized by bromodomains, and recently structurally diverse YEATS domains also emerged as readers of lysine acetyl/acylations. Here we present a crystallography-based strategy and the discovery of… read more here.
Keywords: structure based; toward identification; identification; based approach ... See more keywords
An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01395
Abstract: α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/ N- or O-acylation/intramolecular… read more here.
Keywords: wittig approach; intramolecular wittig; chromenone oximes; approach toward ... See more keywords
Synergistic Approach Toward a Reproducible High zT in n-Type and p-Type Superionic Thermoelectric Ag2Te.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c17039
Abstract: Recently, superionic thermoelectrics have attracted enormous attention due to their ultralow thermal conductivity and high figure-of-merit (zT). However, their high zT is generally obtained deep inside the superionic phase, e.g., near 1000 K in Cu2X… read more here.
Keywords: type type; ag2te; toward reproducible; approach toward ... See more keywords
Exploring an Approach toward the Intrinsic Limits of GaN Electronics
Sign Up to like & getrecommendations! Published in 2020 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.9b19697
Abstract: To fully exploit the advantages of GaN for electronic devices, a critical electric field that approaches its theoretical value (3 MV/cm) is desirable but has not yet been achieved. It is necessary to explore a… read more here.
Keywords: gan electronics; intrinsic limits; toward intrinsic; limits gan ... See more keywords
Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05681
Abstract: The phenylspirodrimanes (PSDs) from Stachybotrys chartarum represent a structurally diverse group of meroterpenoids, which, on the one hand, exhibit a structural exclusivity since their occurrence is not known for any other species and, on the… read more here.
Keywords: semisynthetic approach; approach toward; biologically active; inhibitory activity ... See more keywords
Chemoenzymatic Approach toward the Synthesis of 3-O-(α/β)-Glucosylated 3-Hydroxy-β-lactams
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01969
Abstract: Glycosylation significantly alters the biological and physicochemical properties of small molecules. β-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In this framework, the… read more here.
Keywords: hydroxy lactams; toward synthesis; approach toward; synthesis ... See more keywords