Long path to MYC inhibition approaches clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-019-0141-9
Abstract: Omomyc, a MYC dominant-negative gene product that is used to inhibit MYC for research purposes, can penetrate cancer cells in vitro and in vivo, bringing it closer to evaluation in the clinic. read more here.
Keywords: long path; inhibition approaches; path myc; myc inhibition ... See more keywords
Harnessing neuroplasticity: modern approaches and clinical future
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2018.1466781
Abstract: ABSTRACT Background and purpose: Neurological diseases and injuries to the nervous system may cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would lead to the development of neurological and neurodegenerative disorders which might… read more here.
Keywords: harnessing neuroplasticity; modern approaches; neuroplasticity modern; approaches clinical ... See more keywords
Regularization approaches in clinical biostatistics: A review of methods and their applications
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221133557
Abstract: A range of regularization approaches have been proposed in the data sciences to overcome overfitting, to exploit sparsity or to improve prediction. Using a broad definition of regularization, namely controlling model complexity by adding information… read more here.
Keywords: review methods; regularization; clinical biostatistics; regularization approaches ... See more keywords
FFPE-Based NGS Approaches into Clinical Practice: The Limits of Glory from a Pathologist Viewpoint
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050750
Abstract: The introduction of next-generation sequencing (NGS) in the molecular diagnostic armamentarium is deeply changing pathology practice and laboratory frameworks. NGS allows for the comprehensive molecular characterization of neoplasms, in order to provide the best treatment… read more here.
Keywords: practice; ffpe based; ngs approaches; pathology ... See more keywords
From Immunotoxins to Suicide Toxin Delivery Approaches: Is There a Clinical Opportunity?
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14090579
Abstract: Suicide gene therapy is a relatively novel form of cancer therapy in which a gene coding for enzymes or protein toxins is delivered through targeting systems such as vesicles, nanoparticles, peptide or lipidic co-adjuvants. The… read more here.
Keywords: immunotoxins suicide; suicide toxin; delivery; toxin delivery ... See more keywords